Emerging Evasion Mechanisms of Macrophage Defenses by Pathogenic Bacteria

Clarisse Leseigneur (1, 2) , Pierre Lê-Bury (1, 2) , Javier Pizarro-Cerdá (1, 3, 4) , Olivier Dussurget (1, 2)

1 Yersinia
2 UPCité - Université Paris Cité
3 CNR - Centre National de Référence de la Peste et autres Yersinioses - National Reference Center Plague and Yersinioses
4 CC-OMS / WHO-CC - Centre collaborateur de l'OMS Yersinia - WHO Collaborating Center Yersinia

Macrophages participate to the first line of defense against infectious agents. Microbial pathogens evolved sophisticated mechanisms to escape macrophage killing. Here, we review recent discoveries and emerging concepts on bacterial molecular strategies to subvert macrophage immune responses. We focus on the expanding number of fascinating subversive tools developed by Listeria monocytogenes, Staphylococcus aureus, and pathogenic Yersinia spp., illustrating diversity and commonality in mechanisms used by microorganisms with different pathogenic lifestyles.

Keywords: phagocyte; immune escape; virulence; listeriosis; staphylococcal infection; plague; yersiniosis

Domains: Bacteriology

Clarisse Leseigneur, Pierre Lê-Bury, Javier Pizarro-Cerdá, Olivier Dussurget. Emerging Evasion Mechanisms of Macrophage Defenses by Pathogenic Bacteria. Frontiers in Cellular and Infection Microbiology, 2020, 10, pp.577559. ⟨10.3389/fcimb.2020.577559⟩. ⟨pasteur-03666780⟩