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Complete Nucleotide Sequence of Two Multidrug-Resistant IncR Plasmids from Klebsiella pneumoniae

Abstract : We report here the complete nucleotide sequence of two IncR replicons encoding multidrug resistance determinants, including β-lactam ( bla DHA-1 , bla SHV-12 ), aminoglycoside ( aphA1 , strA , strB ), and fluoroquinolone ( qnrB4 , aac6′-1b-cr ) resistance genes. The plasmids have backbones that are similar to each other, including the replication and stability systems, and contain a wide variety of transposable elements carrying known antibiotic resistance genes. This study confirms the increasing clinical importance of IncR replicons as resistance gene carriers.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-03252020
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Submitted on : Monday, June 7, 2021 - 2:50:46 PM
Last modification on : Wednesday, December 22, 2021 - 6:40:02 PM

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Fabrice Compain, L. Frangeul, Laurence Drieux, Charlotte Verdet, Sylvain Brisse, et al.. Complete Nucleotide Sequence of Two Multidrug-Resistant IncR Plasmids from Klebsiella pneumoniae. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2014, 58 (7), pp.4207-4210. ⟨10.1128/AAC.02773-13⟩. ⟨pasteur-03252020⟩

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