Epidermodysplasia verruciformis-like eruption complicating human immunodeficiency virus infection

C. Barzegar (1) , C. Paul (1) , P. Saiag (2) , P. Cassenot (3) , H. Bachelez (1) , B. Autran (4) , G. Gorochov (4) , A. Petit (5) , L Dubertret (1)

1 AP-HP - Hopital Saint-Louis [AP-HP]
2 Hôpital Ambroise Paré [AP-HP]
3 Papillomavirus
4 CHU Pitié-Salpêtrière [AP-HP]
5 Hôpital Victor Dupouy

Three human immunodeficiency virus (HIV)-infected patients presented with disseminated pityriasis versicolor-like skin lesions. Histological examination showed features characteristic of epidermodysplasia verruciformis (EV). Hybridization studies demonstrated the presence of human papillomavirus (HPV) type 5 (HPV5) DNA in two patients and HPV20 in one. A relative increase in CD8+, CD57+ cells, which are known to inhibit cell-mediated cytolysis, was observed in all patients. HLA-DQB 0301 haplotype, which has been associated with EV, was detected in two patients. The findings suggest that infection with EV-associated HPV types can complicate HIV infection. Both cellular immune defects and a hitherto unknown genetic background might explain the occurrence of EV in HIV-infected patients.

Domaines: Sciences du Vivant [q-bio]

C. Barzegar, C. Paul, P. Saiag, P. Cassenot, H. Bachelez, et al.. Epidermodysplasia verruciformis-like eruption complicating human immunodeficiency virus infection. British Journal of Dermatology, 1998, 139 (1), pp.122-127. ⟨10.1046/j.1365-2133.1998.02328.x⟩. ⟨pasteur-02940308⟩