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Gag p27-Specific B- and T-Cell Responses in Simian Immunodeficiency Virus SIVagm-Infected African Green Monkeys

Abstract : Nonpathogenic simian immunodeficiency virus SIVagm infection of African green monkeys (AGMs) is characterized by the absence of a robust antibody response against Gag p27. To determine if this is accompanied by a selective loss of T-cell responses to Gag p27, we studied CD4 and CD8 T-cell responses against Gag p27 and other SIVagm antigens in the peripheral blood and lymph nodes of acutely and chronically infected AGMs. Our data show that AGMs can mount a T-cell response against Gag p27, indicating that the absence of anti-p27 antibodies is not due to the absence of Gag p27-specific T cells.
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José-Manuel Lozano Reina, David Favre, Zeljka Ka, Véronique Mayau, Marie-Thérèse Nugeyre, et al.. Gag p27-Specific B- and T-Cell Responses in Simian Immunodeficiency Virus SIVagm-Infected African Green Monkeys. Journal of Virology, American Society for Microbiology, 2009, 83 (6), pp.2770-2777. ⟨10.1128/jvi.01841-08⟩. ⟨pasteur-01969024⟩

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