Gag p27-Specific B- and T-Cell Responses in Simian Immunodeficiency Virus SIVagm-Infected African Green Monkeys

José-Manuel Lozano Reina (1) , David Favre (2) , Zeljka Ka (2) , Véronique Mayau (1) , Marie-Thérèse Nugeyre (1) , Thierno Ka (3) , Abdourahmane Faye (3) , Christopher J Miller (4) , Daniel Scott-Algara (1) , Joseph M Mccune (2) , Françoise Barré-Sinoussi (1) , Ousmane M. Diop (3) , Michaela Muller-Trutwin (1)

1 Régulation des Infections Rétrovirales
2 UC San Francisco - University of California [San Francisco]
3 Institut Pasteur de Dakar
4 UC Davis - University of California [Davis]

Nonpathogenic simian immunodeficiency virus SIVagm infection of African green monkeys (AGMs) is characterized by the absence of a robust antibody response against Gag p27. To determine if this is accompanied by a selective loss of T-cell responses to Gag p27, we studied CD4 and CD8 T-cell responses against Gag p27 and other SIVagm antigens in the peripheral blood and lymph nodes of acutely and chronically infected AGMs. Our data show that AGMs can mount a T-cell response against Gag p27, indicating that the absence of anti-p27 antibodies is not due to the absence of Gag p27-specific T cells.

Domaines: Sciences du Vivant [q-bio]; Immunologie; Immunité adaptative; Maladies infectieuses; Microbiologie et Parasitologie; Virologie

José-Manuel Lozano Reina, David Favre, Zeljka Ka, Véronique Mayau, Marie-Thérèse Nugeyre, et al.. Gag p27-Specific B- and T-Cell Responses in Simian Immunodeficiency Virus SIVagm-Infected African Green Monkeys. Journal of Virology, 2009, 83 (6), pp.2770-2777. ⟨10.1128/jvi.01841-08⟩. ⟨pasteur-01969024⟩