High antibody-dependent cellular cytotoxicity responses are correlated with strong CD8 T cell viral suppressive activity but not with B57 status in HIV-1 elite controllers

Olivier Lambotte (1, 2, 3) , Justin Pollara (4) , Faroudy Boufassa (5) , Christiane Moog (6) , Alain Venet (1) , Barton F. Haynes (4) , Jean-François Delfraissy (3, 1, 2) , Asier Saez-Cirion (7) , Guido Ferrari (8)

1 INSERM U1012
2 UP11 - Université Paris-Sud - Paris 11
3 Service de médecine interne et maladies infectieuses
4 Duke School of Medicine
5 CESP - Centre de recherche en épidémiologie et santé des populations
6 Réplication virale, pathogenèse et immunité
7 Régulation des Infections Rétrovirales
8 Duke University Medical Center

The role of Antibody-dependent cellular cytotoxicity (ADCC) responses in HIV-1 controllers is still unclear due to the heterogeneity of these patients. We analyzed 67 HIV-1 controllers and found significantly higher levels of ADCC antibodies in controllers versus viremic subjects (p = 0.017). Moreover, multivariate analysis revealed significantly higher ADCC titers in HLA B57- controllers compared to HLA-B57+ ones (p = 0.0086). These data suggest a role for ADCC in immune control of HIV, especially in HLA B57 negative controllers.

Keywords: Adult; Antibodies; Viral; Antibody-Dependent Cell Cytotoxicity; CD8-Positive T-Lymphocytes; Female; HIV-1; HIV Infections; HIV Long-Term Survivors; HLA-B Antigens; Humans; Linear Models; Male; Middle Aged; Multivariate Analysis; RNA; Viremia

Domains: Immunology

Olivier Lambotte, Justin Pollara, Faroudy Boufassa, Christiane Moog, Alain Venet, et al.. High antibody-dependent cellular cytotoxicity responses are correlated with strong CD8 T cell viral suppressive activity but not with B57 status in HIV-1 elite controllers. PLoS ONE, 2013, 8 (9), pp.e74855. ⟨10.1371/journal.pone.0074855⟩. ⟨pasteur-01420536⟩