GATA-3 Function in Innate and Adaptive Immunity.

Irma Tindemans (1) , Nicolas Serafini (2) , James P Di Santo (2) , Rudi W Hendriks (1)

1 Department of Pulmonary Medicine
2 Immunité Innée - Innate Immunity

: The zinc-finger transcription factor GATA-3 has received much attention as a master regulator of T helper 2 (Th2) cell differentiation, during which it controls interleukin-4 (IL-4), IL-5, and IL-13 expression. More recently, GATA-3 was shown to contribute to type 2 immunity through regulation of group 2 innate lymphoid cell (ILC2) development and function. Furthermore, during thymopoiesis, GATA-3 represses B cell potential in early T cell precursors, activates TCR signaling in pre-T cells, and promotes the CD4(+) T cell lineage after positive selection. GATA-3 also functions outside the thymus in hematopoietic stem cells, regulatory T cells, CD8(+) T cells, thymic natural killer cells, and ILC precursors. Here we discuss the varied functions of GATA-3 in innate and adaptive immune cells, with emphasis on its activity in T cells and ILCs, and examine the mechanistic basis for the dose-dependent, developmental-stage- and cell-lineage-specific activity of this transcription factor.

Domains: Immunology

Irma Tindemans, Nicolas Serafini, James P Di Santo, Rudi W Hendriks. GATA-3 Function in Innate and Adaptive Immunity.. Immunity, 2014, 41 (2), pp.191-206. ⟨10.1016/j.immuni.2014.06.006⟩. ⟨pasteur-01063222⟩