Peripheral T cell survival.

A. A. Freitas (1) , B. Rocha (2)

1 Dynamiques Lymphocytaires
2 INEM - UM 111 (UMR 8253 / U1151) - Institut Necker Enfants-Malades

T cell survival in the periphery is an active process, depending on continuous TCR engagement by peptide-MHC complexes and/or response to environmental cytokines. Naive T cells require interactions with the MHC restricting element. The survival requirements of memory T cells are as yet insufficiently characterized, but MHC-restricted interactions are not necessary.

Domaines: Immunologie

A. A. Freitas, B. Rocha. Peripheral T cell survival.. Current Opinion in Immunology, 1999, 11 (2), pp.152-6. ⟨10.1016/S0952-7915(99)80026-0⟩. ⟨pasteur-00327522⟩