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The invasive proteome of glioblastoma revealed by laser-capture microdissection

Thomas Daubon 1, 2 Joris Guyon 1 Anne-Aurélie Raymond 3 Benjamin Dartigues 4 Justine Rudewicz 4 Zakaria Ezzoukhry 3 Jean-William Dupuy 5 John Herbert 6 Frédéric Saltel 7 Rolf Bjerkvig 8 Macha Nikolski 9, 4 Andreas Bikfalvi 1
1 LAMC - Laboratoire Angiogenèse et Micro-environnement des Cancers
2 UiB - University of Bergen
3 Transbiomed : Biologie Fondamentale et Appliquée à la Médecine
4 CBIB - Centre de Bioinformatique de Bordeaux
5 CGFB - Centre Génomique Fonctionnelle Bordeaux [Bordeaux]
6 Disease Gene Discovery Limited [London, UK]
7 BaRITOn - Bordeaux Research In Translational Oncology [Bordeaux]
8 KG Jebsen Brain Tumor Research Center
9 LaBRI - Laboratoire Bordelais de Recherche en Informatique
Abstract : Background. Glioblastomas are heterogeneous tumors composed of a necrotic and tumor core and an invasive periphery. Methods. Here, we performed a proteomics analysis of laser-capture micro-dissected glioblastoma core and invasive areas of patient-derived xenografts. Results. Bioinformatics analysis identified enriched proteins in central and invasive tumor areas. Novel markers of invasion were identified, the genes proteolipid protein 1 (PLP1) and Dynamin-1 (DNM1), which were subsequently validated in tumors and by functional assays. Conclusions. In summary, our results identify new networks and molecules that may play an important role in glioblastoma development and may constitute potential novel therapeutic targets.
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https://hal.archives-ouvertes.fr/hal-02347439
Contributor : Macha Nikolski Connect in order to contact the contributor
Submitted on : Wednesday, December 9, 2020 - 9:07:29 AM
Last modification on : Wednesday, January 19, 2022 - 2:14:02 PM
Long-term archiving on: : Wednesday, March 10, 2021 - 6:29:17 PM

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CNRS | UNIV-BORDEAUX | CBIB | INSERM | CBB

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Thomas Daubon, Joris Guyon, Anne-Aurélie Raymond, Benjamin Dartigues, Justine Rudewicz, et al.. The invasive proteome of glioblastoma revealed by laser-capture microdissection. Neuro-Oncology Advances, Society for NeuroOncology (SNO); the European Association of Neuro-Oncology(EANO); and Oxford University Press, 2019, 1 (1), pp.1-12. ⟨10.1093/noajnl/vdz029⟩. ⟨hal-02347439⟩

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