Skip to Main content Skip to Navigation
New interface
Journal articles

Human type I IFN deficiency does not impair B cell response to SARS-CoV-2 mRNA vaccination

Aurélien Sokal 1 Paul Bastard 2, 3 Pascal Chappert 1, 4 Giovanna Barba-Spaeth 5 Slim Fourati 6, 4 Alexis Vanderberghe 6, 4 Pauline Lagouge-Roussey 6, 4 Isabelle Meyts 7 Adrian Gervais 2 Magali Bouvier-Alias Imane Azzaoui Ignacio Fernández 5 Andréa de la Selle Qian Zhang Lucy Bizien Isabelle Pellier 8, 9 Agnès Linglart 10, 11 Anya Rothenbuhler Estelle Marcoux 12 Raphael Anxionnat 13 Nathalie Cheikh 13 Juliane Léger 14 Blanca Amador-Borrero 15 Fanny Fouyssac 16 Vanessa Menut 17 Jean-Christophe Goffard 18 Caroline Storey 19 Caroline Demily 20 Coralie Mallebranche Jesus Troya 21 Aurora Pujol 22 Marie Zins 23, 11, 24 Pierre Tiberghien 25 Paul Gray 26, 27 Peter Mcnaughton 28 Anna Sullivan 28 Jane Peake 28 Romain Levy 2, 29 Laetitia Languille Carlos Rodiguez-Gallego 30 Bertrand Boisson Sébastien Gallien Bénédicte Neven Marc Michel Bertrand Godeau Laurent Abel Felix Rey 5 Jean-Claude Weill Claude-Agnès Reynaud Stuart Tangye 31, 27 Jean-Laurent Casanova 2, 29, 3, 32 Matthieu Mahévas 1, 4 
Abstract : Inborn and acquired deficits of type I interferon (IFN) immunity predispose to life-threatening COVID-19 pneumonia. We longitudinally profiled the B cell response to mRNA vaccination in SARS-CoV-2 naive patients with inherited TLR7, IRF7, or IFNAR1 deficiency, as well as young patients with autoantibodies neutralizing type I IFNs due to autoimmune polyendocrine syndrome type-1 (APS-1) and older individuals with age-associated autoantibodies to type I IFNs. The receptor-binding domain spike protein (RBD)–specific memory B cell response in all patients was quantitatively and qualitatively similar to healthy donors. Sustained germinal center responses led to accumulation of somatic hypermutations in immunoglobulin heavy chain genes. The amplitude and duration of, and viral neutralization by, RBD-specific IgG serological response were also largely unaffected by TLR7, IRF7, or IFNAR1 deficiencies up to 7 mo after vaccination in all patients. These results suggest that induction of type I IFN is not required for efficient generation of a humoral response against SARS-CoV-2 by mRNA vaccines.
Document type :
Journal articles
Complete list of metadata
Contributor : Giovanna Barba Spaeth Connect in order to contact the contributor
Submitted on : Thursday, November 10, 2022 - 3:38:43 PM
Last modification on : Friday, November 18, 2022 - 3:34:59 AM


Publication funded by an institution


Distributed under a Creative Commons Attribution - NonCommercial - ShareAlike 4.0 International License



Aurélien Sokal, Paul Bastard, Pascal Chappert, Giovanna Barba-Spaeth, Slim Fourati, et al.. Human type I IFN deficiency does not impair B cell response to SARS-CoV-2 mRNA vaccination. Journal of Experimental Medicine, 2023, 220 (1), pp.e20220258. ⟨10.1084/jem.20220258⟩. ⟨pasteur-03847416⟩



Record views


Files downloads