The role of neutrophils in antibody-driven autoimmune cytopenias

Vanessa Krémer (1, 2) , Luc de Chaisemartin (1, 2, 3) , Friederike Jönsson (1, 4)

1 Anticorps en thérapie et pathologie - Antibodies in Therapy and Pathology
2 MI2 - Inflammation, microbiome, immunosurveillance
3 AP-HP - Hôpital Bichat - Claude Bernard [Paris]
4 CNRS - Centre National de la Recherche Scientifique

Autoimmune cytopenias are a consequence of autoantibodies that target blood cell lineages and mark them for their accelerated destruction, mostly through phagocytosis by monocytes and macrophages and complement activation. Neutrophils, although equipped with Fc and complement receptors and effector mechanisms that are critical in other autoimmune conditions, remained long time overlooked. Recent reports however propose a new and possibly critical role for neutrophils. In this review we gathered available evidences on the contribution of neutrophils to the development, onset and consequences of autoantibody-dependent cytopenias.

Keywords: neutrophils; autoimmune cytopenias; ITP; AIHA; AIN

Domains: Immunology

Vanessa Krémer, Luc de Chaisemartin, Friederike Jönsson. The role of neutrophils in antibody-driven autoimmune cytopenias. International Journal of Biochemistry and Cell Biology, 2022, 147, pp.106231. ⟨10.1016/j.biocel.2022.106231⟩. ⟨pasteur-03754968⟩