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The role of neutrophils in antibody-driven autoimmune cytopenias

Abstract : Autoimmune cytopenias are a consequence of autoantibodies that target blood cell lineages and mark them for their accelerated destruction, mostly through phagocytosis by monocytes and macrophages and complement activation. Neutrophils, although equipped with Fc and complement receptors and effector mechanisms that are critical in other autoimmune conditions, remained long time overlooked. Recent reports however propose a new and possibly critical role for neutrophils. In this review we gathered available evidences on the contribution of neutrophils to the development, onset and consequences of autoantibody-dependent cytopenias.
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Contributor : Friederike Jönsson Connect in order to contact the contributor
Submitted on : Saturday, August 20, 2022 - 4:08:41 PM
Last modification on : Tuesday, September 13, 2022 - 3:08:07 PM


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Vanessa Krémer, Luc de Chaisemartin, Friederike Jönsson. The role of neutrophils in antibody-driven autoimmune cytopenias. The International Journal of Biochemistry & Cell Biology, 2022, 147, pp.106231. ⟨10.1016/j.biocel.2022.106231⟩. ⟨pasteur-03754968⟩



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