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Highly Sensitive Virome Characterization of Aedes aegypti and Culex pipiens Complex from Central Europe and the Caribbean Reveals Potential for Interspecies Viral Transmission

Abstract : Mosquitoes are the most important vectors for arthropod-borne viral diseases. Mixed viral infections of mosquitoes allow genetic recombination or reassortment of diverse viruses, turning mosquitoes into potential virologic mixing bowls. In this study, we field-collected mosquitoes of different species (Aedes aegypti and Culex pipiens complex), from different geographic locations and environments (central Europe and the Caribbean) for highly sensitive next-generation sequencing-based virome characterization. We found a rich virus community associated with a great diversity of host species. Among those, we detected a large diversity of novel virus sequences that we could predominately assign to circular Rep-encoding single-stranded (CRESS) DNA viruses, including the full-length genome of a yet undescribed Gemykrogvirus species. Moreover, we report for the first time the detection of a potentially zoonotic CRESS-DNA virus (Cyclovirus VN) in mosquito vectors. This study expands the knowledge on virus diversity in medically important mosquito vectors, especially for CRESS-DNA viruses that have previously been shown to easily recombine and jump the species barrier.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-03700631
Contributor : Nicolas Rascovan Connect in order to contact the contributor
Submitted on : Tuesday, June 21, 2022 - 12:10:35 PM
Last modification on : Tuesday, June 21, 2022 - 2:49:50 PM

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Distributed under a Creative Commons Attribution 4.0 International License

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Jakob Thannesberger, Nicolas Rascovan, Anna Eisenmann, Ingeborg Klymiuk, Carina Zittra, et al.. Highly Sensitive Virome Characterization of Aedes aegypti and Culex pipiens Complex from Central Europe and the Caribbean Reveals Potential for Interspecies Viral Transmission. Pathogens, MDPI, 2020, Special Issue Translational Research for Zoonotic Parasites: New Findings toward Improved Diagnostics, Therapy and Prevention, 9 (9), pp.686. ⟨10.3390/pathogens9090686⟩. ⟨pasteur-03700631⟩

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