Transmission of SARS-CoV-2 Alpha Variant (B.1.1.7) From a BNT162b2-Vaccinated Individual

Solen Kernéis (1, 2) , Delphine Planas (3, 4, 5) , Sandrine Imbeaud (6) , Isabelle Staropoli (3, 4, 5) , Julien Puech (7) , Nicolas Robillard (7) , Julien Rodary (7) , Timothée Bruel (3, 4, 5) , Thomas Vieillard (8) , Olivier Schwartz (3, 4, 5) , Laurent Belec (7, 9, 10) , Hélène Péré (6) , David Veyer (6, 7)

1 AP-HP - Hôpital Bichat - Claude Bernard [Paris]
2 IAME (UMR_S_1137 / U1137) - Infection, Anti-microbiens, Modélisation, Evolution
3 CNRS-UMR3569 - Virus et Immunité - Virus and immunity
4 VRI - Vaccine Research Institute
5 IMRB - Institut Mondor de Recherche Biomédicale
6 CRC (UMR_S_1138 / U1138) - Centre de Recherche des Cordeliers
7 HEGP - Hôpital Européen Georges Pompidou [APHP]
8 Laboratoire Biosmose-idf [Rueil-Malmaison]
9 PARCC (UMR_S 970/ U970) - Paris-Centre de Recherche Cardiovasculaire
10 UPCité UFR Médecine - Université Paris Cité - UFR Médecine [Santé]

Cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) acquisition after vaccination with BNT162b2 have been described, but the risk of secondary transmission from fully vaccinated individuals remains ill defined. Herein we report a confirmed transmission of SARS-CoV-2 alpha variant (B.1.1.7) from a symptomatic immunocompetent woman 4 weeks after her second dose of BNT162b2, despite antispike seroconversion.

Keywords: BNT162b2; SARS-CoV-2; transmission; vaccination

Domains: Life Sciences [q-bio]; Microbiology and Parasitology; Virology

Solen Kernéis, Delphine Planas, Sandrine Imbeaud, Isabelle Staropoli, Julien Puech, et al.. Transmission of SARS-CoV-2 Alpha Variant (B.1.1.7) From a BNT162b2-Vaccinated Individual. Open Forum Infectious Diseases, 2021, 8 (8), pp.ofab369. ⟨10.1093/ofid/ofab369⟩. ⟨pasteur-03696825⟩