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Reconstructing 50,000 years of human history from our DNA: lessons from modern genomics

Abstract : The advent of high throughput sequencing approaches and ancient DNA techniques have enabled reconstructing the history of human populations at an unprecedented level of resolution. The symposium from the French Academy of Sciences "50,000 ans d'épopée humaine dans notre ADN" has reviewed some of the latest contributions from the fields of genomics, archaeology, and linguistics to our understanding of >300,000 years of human history. DNA has revealed the richness of the human journey, from the deep divergences between human populations in Africa, to the first encounters of Homo Sapiens with other hominins on their way to Eurasia and the peopling of Remote Oceania. The symposium has also emphasized how migrations, cultural practices, and environmental pathogens have contributed to shape the genetic diversity of modern humans, through admixture, genetic drift or genetic adaptation. Finally, special attention was also given to how human behaviours have shaped the genome of other species, through the spreading of microbes and pathogens, as in the case of Yersinia Pestis, or through domestication, as elegantly demonstrated for dogs, horses, and apples. Altogether, this conference illustrated how the complex history of human populations is tightly linked with their contemporary genetic diversity that, in turn, has direct effects on their identity and health.
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Contributor : Maxime ROTIVAL Connect in order to contact the contributor
Submitted on : Thursday, June 16, 2022 - 10:43:55 AM
Last modification on : Friday, June 17, 2022 - 10:56:17 AM


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Maxime Rotival, Pascale Cossart, Lluis Quintana-Murci. Reconstructing 50,000 years of human history from our DNA: lessons from modern genomics. Comptes Rendus. Biologies, 2021, 344 (2), pp.177-187. ⟨10.5802/crbiol.55⟩. ⟨pasteur-03696701⟩



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