Systematic Booster after Rabies Pre-Exposure Prophylaxis to Alleviate Rabies Antibody Monitoring in Individuals at Risk of Occupational Exposure - Archive ouverte HAL Access content directly
Journal Articles Vaccines Year : 2021

Systematic Booster after Rabies Pre-Exposure Prophylaxis to Alleviate Rabies Antibody Monitoring in Individuals at Risk of Occupational Exposure

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Jérémie Sommé
  • Function : Author
  • PersonId : 1141815
Agnès Durand
  • Function : Author
  • PersonId : 1133486
Anne-Sophie Le Guern
  • Function : Author
  • PersonId : 1068379
Marie-Laurence Mousel
  • Function : Author
  • PersonId : 1133489
Beata Francuz
  • Function : Author
  • PersonId : 1133490

Abstract

Pre-exposure rabies prophylaxis (PrEP) is recommended for people at frequent or increased risk of professional exposure to lyssavirus (including rabies virus). PrEP provides protection against unrecognized exposure. After the primary vaccination, one's immune response against rabies may decline over time. We aimed to evaluate the immune response to rabies in individuals immunized for occupational reasons before and after a booster dose of the rabies vaccine. With this aim, we retrospectively documented factors associated with an inadequate response in individuals vaccinated for occupational purposes. Our findings analyzed data from 498 vaccinated individuals and found that 17.2% of participants had an inadequate antibody titration documented after their primary vaccination without the booster, while inadequate response after an additional booster of the vaccine was evidenced in 0.5% of tested participants. This study showed that a single booster dose of vaccine after PrEP conferred a high and long-term immune response in nearly all individuals except for rare, low responders. A systematic rabies booster after primary vaccination may result in alleviating the monitoring strategy of post-PrEP antibody titers among exposed professionals.
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pasteur-03655265 , version 1 (29-04-2022)

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Attribution - CC BY 4.0

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Perrine Parize, Jérémie Sommé, Laura Schaeffer, Agnès Durand, Florence Ribadeau-Dumas, et al.. Systematic Booster after Rabies Pre-Exposure Prophylaxis to Alleviate Rabies Antibody Monitoring in Individuals at Risk of Occupational Exposure. Vaccines, 2021, 9 (4), pp.309. ⟨10.3390/vaccines9040309⟩. ⟨pasteur-03655265⟩
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