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Journal articles
Trained ILC3 responses promote intestinal defense
Nicolas Serafini
1
Angélique Jarade
1
Laura Surace
1
Pedro Goncalves
1
Odile Sismeiro
2
Hugo Varet
2, 3
Rachel Legendre
2, 3
Jean-Yves Coppee
2
Olivier Disson
4
Scott Durum
4
Gad Frankel
5
James Di Santo
1
Odile Sismeiro 2
Author
Hugo Varet 2, 3
Author IdHAL : hugo-varet ORCID : https://orcid.org/0000-0003-3980-4463
Rachel Legendre 2, 3
Author IdHAL : rachel-legendre ORCID : https://orcid.org/0000-0002-5196-9431
Jean-Yves Coppee 2
Author
1
Immunité Innée - Innate Immunity (Département d'Immunologie, 25-28 rue du Docteur Roux, 75724 Paris Cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1223 (101, rue de Tolbiac, 75013 Paris - France)
- UPC - Université Paris Cité (85 boulevard Saint-Germain 75006 Paris - France)
2
Biomics (plateforme technologique) (Centre de Ressources et Recherches technologiques (C2RT), Département Génomes et Génétique -25-28 rue du Docteur Roux, 75724 Paris cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
- UPC - Université Paris Cité (85 boulevard Saint-Germain 75006 Paris - France)
3
Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB (Département de biologie computationnelle (ex C3BI), 25-28 rue du Docteur Roux, 75724 Paris cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
- CNRS - Centre National de la Recherche Scientifique : USR3756 (France)
4
Biologie des Infections - Biology of Infection (Département de Biologie cellulaire et Infection, 25-28, rue du docteur Roux, 75724 Paris Cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1117 (101, rue de Tolbiac, 75013 Paris - France)
- UPC - Université Paris Cité (85 boulevard Saint-Germain 75006 Paris - France)
5
Imperial College London (South Kensington Campus, London SW7 2AZ - United Kingdom)
Abstract : Group 3 innate lymphoid cells (ILC3s) are innate immune effectors that contribute to host defense. Whether ILC3 functions are stably modified after pathogen encounter is unknown. Here, we assess the impact of a time-restricted enterobacterial challenge to long-term ILC3 activation in mice. We found that intestinal ILC3s persist for months in an activated state after exposure to Citrobacter rodentium . Upon rechallenge, these “trained” ILC3s proliferate, display enhanced interleukin-22 (IL-22) responses, and have a superior capacity to control infection compared with naïve ILC3s. Metabolic changes occur in C. rodentium –exposed ILC3s, but only trained ILC3s have an enhanced proliferative capacity that contributes to increased IL-22 production. Accordingly, a limited encounter with a pathogen can promote durable phenotypic and functional changes in intestinal ILC3s that contribute to long-term mucosal defense.
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Journal articles
Domain :
Complete list of metadata
https://hal-pasteur.archives-ouvertes.fr/pasteur-03590719
Contributor : Hugo Varet Connect in order to contact the contributor
Submitted on : Monday, February 28, 2022 - 10:13:58 AM
Last modification on : Tuesday, May 10, 2022 - 2:42:05 PM
Contributor : Hugo Varet Connect in order to contact the contributor
Submitted on : Monday, February 28, 2022 - 10:13:58 AM
Last modification on : Tuesday, May 10, 2022 - 2:42:05 PM
Identifiers
- HAL Id : pasteur-03590719, version 1
- DOI : 10.1126/science.aaz8777
- PUBMED : 35201883
Collections
PASTEUR | CNRS | UNIV-PARIS
Citation
Nicolas Serafini, Angélique Jarade, Laura Surace, Pedro Goncalves, Odile Sismeiro, et al.. Trained ILC3 responses promote intestinal defense. Science, American Association for the Advancement of Science (AAAS), 2022, 375 (6583), pp.859-863. ⟨10.1126/science.aaz8777⟩. ⟨pasteur-03590719⟩
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