Trained ILC3 responses promote intestinal defense - Archive ouverte HAL Access content directly
Journal Articles Science Year : 2022

Trained ILC3 responses promote intestinal defense

(1) , (1) , (1) , (1) , (2) , (2, 3) , (2, 3) , (2) , (4) , (4) , (5) , (1)
1
2
3
4
5

Abstract

Group 3 innate lymphoid cells (ILC3s) are innate immune effectors that contribute to host defense. Whether ILC3 functions are stably modified after pathogen encounter is unknown. Here, we assess the impact of a time-restricted enterobacterial challenge to long-term ILC3 activation in mice. We found that intestinal ILC3s persist for months in an activated state after exposure to Citrobacter rodentium . Upon rechallenge, these “trained” ILC3s proliferate, display enhanced interleukin-22 (IL-22) responses, and have a superior capacity to control infection compared with naïve ILC3s. Metabolic changes occur in C. rodentium –exposed ILC3s, but only trained ILC3s have an enhanced proliferative capacity that contributes to increased IL-22 production. Accordingly, a limited encounter with a pathogen can promote durable phenotypic and functional changes in intestinal ILC3s that contribute to long-term mucosal defense.
Not file

Dates and versions

pasteur-03590719 , version 1 (28-02-2022)

Identifiers

Cite

Nicolas Serafini, Angélique Jarade, Laura Surace, Pedro Goncalves, Odile Sismeiro, et al.. Trained ILC3 responses promote intestinal defense. Science, 2022, 375 (6583), pp.859-863. ⟨10.1126/science.aaz8777⟩. ⟨pasteur-03590719⟩
28 View
2 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More