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Mechanisms supporting aminoadenine-based viral DNA genomes

Abstract : Bacteriophage genomes are the richest source of modified nucleobases of any life form. Of these, 2,6 diaminopurine, which pairs with thymine by forming three hydrogen bonds violates Watson and Crick’s base pairing. 2,6 diaminopurine initially found in the cyanophage S-2L is more widespread than expected and has also been detected in phage infecting Gram-negative and Gram-positive bacteria. The biosynthetic pathway for aminoadenine containing DNA as well as the exclusion of adenine are now elucidated. This example of a natural deviation from the genetic code represents only one of the possibilities explored by nature and provides a proof of concept for the synthetic biology of non-canonical nucleic acids.
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Contributor : pierre alexandre Kaminski Connect in order to contact the contributor
Submitted on : Thursday, February 24, 2022 - 3:48:53 PM
Last modification on : Friday, August 5, 2022 - 12:02:57 PM
Long-term archiving on: : Wednesday, May 25, 2022 - 8:25:05 PM


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Pierre-Alexandre Kaminski. Mechanisms supporting aminoadenine-based viral DNA genomes. Cellular and Molecular Life Sciences, Springer Verlag, 2022, 79 (1), pp.51. ⟨10.1007/s00018-021-04055-7⟩. ⟨pasteur-03549987⟩



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