Evolution of VIM-1-Producing Klebsiella pneumoniae Isolates from a Hospital Outbreak Reveals the Genetic Bases of the Loss of the Urease-Positive Identification Character

Nicolas Cabanel (1) , Isabelle Rosinski-Chupin (1) , Adriana Chiarelli (1, 2) , Tatiana Botin (1) , Marta Tato (3) , Rafael Canton (3) , Philippe Glaser (1)

1 EERA - Ecologie et Evolution de la Résistance aux Antibiotiques / Ecology and Evolution of Antibiotics Resistance
2 USPC - Université Sorbonne Paris Cité
3 Hospital Universitario Ramón y Cajal [Madrid]

Evolution of multidrug-resistant bacterial pathogens occurs at multiple scales, in the patient, locally in the hospital, or more globally. Some mutations or gene acquisitions, for instance in response to antibiotic treatment, may be restricted to a single patient due to their high fitness cost.

Keywords: Klebsiella pneumoniae; carbapenemase; drug resistance evolution; insertion sequence; mobile genetic elements; urease

Domains: Biochemistry, Molecular Biology

Nicolas Cabanel, Isabelle Rosinski-Chupin, Adriana Chiarelli, Tatiana Botin, Marta Tato, et al.. Evolution of VIM-1-Producing Klebsiella pneumoniae Isolates from a Hospital Outbreak Reveals the Genetic Bases of the Loss of the Urease-Positive Identification Character. mSystems, 2021, 6 (3), pp.e0024421. ⟨10.1128/mSystems.00244-21⟩. ⟨pasteur-03519675⟩