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Colonization of dermal arterioles by Neisseria meningitidis provides a safe haven from neutrophils

Abstract : Abstract The human pathogen Neisseria meningitidis can cause meningitis and fatal systemic disease. The bacteria colonize blood vessels and rapidly cause vascular damage, despite a neutrophil-rich inflammatory infiltrate. Here, we use a humanized mouse model to show that vascular colonization leads to the recruitment of neutrophils, which partially reduce bacterial burden and vascular damage. This partial effect is due to the ability of bacteria to colonize capillaries, venules and arterioles, as observed in human samples. In venules, potent neutrophil recruitment allows efficient bacterial phagocytosis. In contrast, in infected capillaries and arterioles, adhesion molecules such as E-Selectin are not expressed on the endothelium, and intravascular neutrophil recruitment is minimal. Our results indicate that the colonization of capillaries and arterioles by N. meningitidis creates an intravascular niche that precludes the action of neutrophils, resulting in immune escape and progression of the infection.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-03479345
Contributor : Dorian Obino Connect in order to contact the contributor
Submitted on : Tuesday, December 14, 2021 - 11:51:03 AM
Last modification on : Friday, August 5, 2022 - 12:03:10 PM

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Distributed under a Creative Commons Attribution 4.0 International License

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Valeria Manriquez, Pierre Nivoit, Tomas Urbina, Hebert Echenique-Rivera, Keira Melican, et al.. Colonization of dermal arterioles by Neisseria meningitidis provides a safe haven from neutrophils. Nature Communications, 2021, 12 (1), pp.4547. ⟨10.1038/s41467-021-24797-z⟩. ⟨pasteur-03479345⟩

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