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Journal Articles Nature Communications Year : 2021

Circulation of pertussis and poor protection against diphtheria among middle-aged adults in 18 European countries

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Julie Toubiana
Tatjana Kolupajeva
  • Function : Author
Serosurveillance Study Team
  • Function : Author

Abstract

Reported incidence of pertussis in the European Union (EU) and the European Economic Area (EEA) varies and may not reflect the real situation, while vaccine-induced protection against diphtheria and tetanus seems sufficient. We aimed to determine the seroprevalence of DTP antibodies in EU/EEA countries within the age groups of 40–49 and 50–59 years. Eighteen countries collected around 500 samples between 2015 and 2018 (N = 10,302) which were analysed for IgG-DTP specific antibodies. The proportion of sera with pertussis toxin antibody levels ≥100 IU/mL, indicative of recent exposure to pertussis was comparable for 13/18 countries, ranging between 2.7–5.8%. For diphtheria the proportion of sera lacking the protective level (<0.1 IU/mL) varied between 22.8–82.0%. For tetanus the protection was sufficient. Here, we report that the seroprevalence of pertussis in these age groups indicates circulation of B. pertussis across EU/EEA while the lack of vaccine-induced seroprotection against diphtheria is of concern and deserves further attention.
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Origin : Publication funded by an institution

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pasteur-03327912 , version 1 (27-08-2021)

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Attribution - CC BY 4.0

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Guy Berbers, Pieter van Gageldonk, Jan van De Kassteele, Ursula Wiedermann, Isabelle Desombere, et al.. Circulation of pertussis and poor protection against diphtheria among middle-aged adults in 18 European countries. Nature Communications, 2021, 12 (1), pp.2871. ⟨10.1038/s41467-021-23114-y⟩. ⟨pasteur-03327912⟩

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