Abstract : Reported incidence of pertussis in the European Union (EU) and the European Economic Area (EEA) varies and may not reflect the real situation, while vaccine-induced protection against diphtheria and tetanus seems sufficient. We aimed to determine the seroprevalence of DTP antibodies in EU/EEA countries within the age groups of 40–49 and 50–59 years. Eighteen countries collected around 500 samples between 2015 and 2018 (N = 10,302) which were analysed for IgG-DTP specific antibodies. The proportion of sera with pertussis toxin antibody levels ≥100 IU/mL, indicative of recent exposure to pertussis was comparable for 13/18 countries, ranging between 2.7–5.8%. For diphtheria the proportion of sera lacking the protective level (<0.1 IU/mL) varied between 22.8–82.0%. For tetanus the protection was sufficient. Here, we report that the seroprevalence of pertussis in these age groups indicates circulation of B. pertussis across EU/EEA while the lack of vaccine-induced seroprotection against diphtheria is of concern and deserves further attention.
https://hal-pasteur.archives-ouvertes.fr/pasteur-03327912 Contributor : Sylvain BrisseConnect in order to contact the contributor Submitted on : Friday, August 27, 2021 - 4:23:07 PM Last modification on : Thursday, April 7, 2022 - 10:10:46 AM Long-term archiving on: : Sunday, November 28, 2021 - 6:47:56 PM
Guy Berbers, Pieter van Gageldonk, Jan van De Kassteele, Ursula Wiedermann, Isabelle Desombere, et al.. Circulation of pertussis and poor protection against diphtheria among middle-aged adults in 18 European countries. Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.2871. ⟨10.1038/s41467-021-23114-y⟩. ⟨pasteur-03327912⟩