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Circulation of pertussis and poor protection against diphtheria among middle-aged adults in 18 European countries

Guy Berbers 1, * Pieter van Gageldonk 1 Jan van De Kassteele 1 Ursula Wiedermann 2 Isabelle Desombere 3 Tine Dalby 4 Julie Toubiana 5 Sotirios Tsiodras 6 Ildikó Paluska Ferencz 7 Kathryn Mullan 8 Algirdas Griskevicius 9 Tatjana Kolupajeva 10 Didrik Frimann Vestrheim 11 Paula Palminha 12 Odette Popovici 13 Lena Wehlin 14 Tamara Kastrin 15 Lucia Maďarová 16 Helen Campbell 17 Csaba Ködmön 18 Sabrina Bacci 18 Alex-Mikael Barkoff 19 Qiushui He 19, 20, * Serosurveillance Study Team
* Corresponding author
1 RIVM - National Institute for Public Health and the Environment [Bilthoven]
2 Medizinische Universität Wien = Medical University of Vienna
3 Sciensano [Bruxelles]
4 Statens Serum Institut [Copenhagen]
5 Institut Pasteur [Paris]
6 Hellenic Center for Disease Control and Prevention
7 OEK - National Center for Epidemiology - Országos Epidemiológiai Központ [Budapest]
8 UCD - University College Dublin [Dublin]
9 NPHSL - National Public Health Surveillance Laboratory [Vilnius, Lithuania]
10 NRL [Riga]
11 NIPH - Norwegian Institute of Public Health [Oslo]
12 INSA - Instituto Nacional de Saùde Dr Ricardo Jorge [Portugal]
13 INSP - National Institute of Public Health [Romania]
14 Public Health Agency of Sweden
15 NLZOH - Slovenia National Laboratory of Health, Environment and Food [Ljubljana, Slovenia]
16 RAPH - Regional Authority of Public Health [Slovaquia]
17 Public Health England [London]
18 ECDC - European Centre for Disease Prevention and Control
19 University of Turku
20 CUMS - Capital University of Medical Sciences [Beijing]
Abstract : Reported incidence of pertussis in the European Union (EU) and the European Economic Area (EEA) varies and may not reflect the real situation, while vaccine-induced protection against diphtheria and tetanus seems sufficient. We aimed to determine the seroprevalence of DTP antibodies in EU/EEA countries within the age groups of 40–49 and 50–59 years. Eighteen countries collected around 500 samples between 2015 and 2018 (N = 10,302) which were analysed for IgG-DTP specific antibodies. The proportion of sera with pertussis toxin antibody levels ≥100 IU/mL, indicative of recent exposure to pertussis was comparable for 13/18 countries, ranging between 2.7–5.8%. For diphtheria the proportion of sera lacking the protective level (<0.1 IU/mL) varied between 22.8–82.0%. For tetanus the protection was sufficient. Here, we report that the seroprevalence of pertussis in these age groups indicates circulation of B. pertussis across EU/EEA while the lack of vaccine-induced seroprotection against diphtheria is of concern and deserves further attention.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-03327912
Contributor : Sylvain Brisse <>
Submitted on : Friday, August 27, 2021 - 4:23:07 PM
Last modification on : Saturday, August 28, 2021 - 3:09:16 AM

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Guy Berbers, Pieter van Gageldonk, Jan van De Kassteele, Ursula Wiedermann, Isabelle Desombere, et al.. Circulation of pertussis and poor protection against diphtheria among middle-aged adults in 18 European countries. Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.2871. ⟨10.1038/s41467-021-23114-y⟩. ⟨pasteur-03327912⟩

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