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Primary Mammary Organoid Model of Lactation and Involution

Abstract : Mammary gland development occurs mainly after birth and is composed of three successive stages: puberty, pregnancy and lactation, and involution. These developmental stages are associated with major tissue remodeling, including extensive changes in mammary epithelium, as well as surrounding stroma. Three-dimensional (3D) mammary organoid culture has become an important tool in mammary gland biology and enabled invaluable discoveries on pubertal mammary branching morphogenesis and breast cancer. However, a suitable 3D organoid model recapitulating key aspects of lactation and involution has been missing. Here, we describe a robust and straightforward mouse mammary organoid system modeling lactation and involutionlike process, which can be applied to study mechanisms of physiological mammary gland lactation and involution as well as pregnancy-associated breast cancer.
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Contributor : Aurélie Chiche <>
Submitted on : Thursday, August 19, 2021 - 10:40:51 AM
Last modification on : Saturday, August 21, 2021 - 3:26:46 AM

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2020 - Sumbal et al., Front De...
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Jakub Sumbal, Aurélie Chiche, Elsa Charifou, Zuzana Koledova, Han Li. Primary Mammary Organoid Model of Lactation and Involution. Frontiers in Cell and Developmental Biology, Frontiers media, 2020, 8, pp.68. ⟨10.3389/fcell.2020.00068⟩. ⟨pasteur-03322452⟩

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