Skip to Main content Skip to Navigation
Journal articles

Primary Mammary Organoid Model of Lactation and Involution

Abstract : Mammary gland development occurs mainly after birth and is composed of three successive stages: puberty, pregnancy and lactation, and involution. These developmental stages are associated with major tissue remodeling, including extensive changes in mammary epithelium, as well as surrounding stroma. Three-dimensional (3D) mammary organoid culture has become an important tool in mammary gland biology and enabled invaluable discoveries on pubertal mammary branching morphogenesis and breast cancer. However, a suitable 3D organoid model recapitulating key aspects of lactation and involution has been missing. Here, we describe a robust and straightforward mouse mammary organoid system modeling lactation and involutionlike process, which can be applied to study mechanisms of physiological mammary gland lactation and involution as well as pregnancy-associated breast cancer.
Document type :
Journal articles
Complete list of metadata
Contributor : Aurélie Chiche Connect in order to contact the contributor
Submitted on : Thursday, August 19, 2021 - 10:40:51 AM
Last modification on : Thursday, April 7, 2022 - 10:10:46 AM
Long-term archiving on: : Saturday, November 20, 2021 - 6:49:29 PM


2020 - Sumbal et al., Front De...
Publication funded by an institution


Distributed under a Creative Commons Attribution 4.0 International License




Jakub Sumbal, Aurélie Chiche, Elsa Charifou, Zuzana Koledova, Han Li. Primary Mammary Organoid Model of Lactation and Involution. Frontiers in Cell and Developmental Biology, Frontiers media, 2020, 8, pp.68. ⟨10.3389/fcell.2020.00068⟩. ⟨pasteur-03322452⟩



Record views


Files downloads