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Genetic effects on the commensal microbiota in inflammatory bowel disease patients

Hugues Aschard 1, 2, * Vincent Laville 1 Eric Tchetgen Tchetgen 3 Dan Knights 4, 5, 6 Floris Imhann 7 Philippe Seksik 8 Noah Zaitlen 9 Mark Silverberg 10 Jacques Cosnes 8 Rinse Weersma 7 Ramnik Xavier 5, 6 Laurent Beaugerie 8, 11 David Skurnik 6, 12, * Harry Sokol 8, 11, 13, 14, *
* Corresponding author
1 C3BI - Centre de Bioinformatique, Biostatistique et Biologie Intégrative
2 Harvard T.H. Chan School of Public Health
3 The Wharton School
4 UMN - University of Minnesota [Twin Cities]
5 BROAD INSTITUTE - Broad Institute of MIT and Harvard
6 HMS - Harvard Medical School [Boston]
7 University of Groningen [Groningen]
8 Service de Gastroentérologie et nutrition [CHU Saint-Antoine]
9 University of California
10 MSH - Mount Sinai Hospital [Toronto, Canada]
11 SU - Sorbonne Université
12 INEM - UM 111 (UMR 8253 / U1151) - Institut Necker Enfants-Malades
13 MICALIS - MICrobiologie de l'ALImentation au Service de la Santé
14 CR Saint-Antoine - Centre de Recherche Saint-Antoine
Abstract : Several bacteria in the gut microbiota have been shown to be associated with inflammatory bowel disease (IBD), and dozens of IBD genetic variants have been identified in genome-wide association studies. However, the role of the microbiota in the etiology of IBD in terms of host genetic susceptibility remains unclear. Here, we studied the association between four major genetic variants associated with an increased risk of IBD and bacterial taxa in up to 633 IBD cases. We performed systematic screening for associations, identifying and replicating associations between NOD2 variants and two taxa: the Roseburia genus and the Faecalibacterium prausnitzii species. By exploring the overall association patterns between genes and bacteria, we found that IBD risk alleles were significantly enriched for associations concordant with bacteria-IBD associations. To understand the significance of this pattern in terms of the study design and known effects from the literature, we used counterfactual principles to assess the fitness of a few parsimonious gene-bacteria-IBD causal models. Our analyses showed evidence that the disease risk of these genetic variants were likely to be partially mediated by the microbiome. We confirmed these results in extensive simulation studies and sensitivity analyses using the association between NOD2 and F. prausnitzii as a case study.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-03278619
Contributor : Hugues Aschard <>
Submitted on : Monday, July 5, 2021 - 5:30:58 PM
Last modification on : Tuesday, July 13, 2021 - 3:29:28 AM

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PASTEUR | INRA | U938 | AGROPARISTECH | SU-MEDECINE | CNRS | INRAE | UP-SANTE | SU-TI | GS-BIOSPHERA | GS-HEALTH-DRUG-SCIENCES | INSERM | SORBONNE-UNIVERSITE

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Hugues Aschard, Vincent Laville, Eric Tchetgen Tchetgen, Dan Knights, Floris Imhann, et al.. Genetic effects on the commensal microbiota in inflammatory bowel disease patients. PLoS Genetics, Public Library of Science, 2019, 15 (3), pp.e1008018. ⟨10.1371/journal.pgen.1008018⟩. ⟨pasteur-03278619⟩

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