Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration - Archive ouverte HAL Access content directly
Journal Articles Nature Communications Year : 2019

Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration

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Maris Alver
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Nicholette Palmer
  • Function : Author
Rainer Rauramaa
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Xiao-Ou Shu
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Stefan Weiss
  • Function : Author
Wanqing Wen
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Lisa Yanek
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Christie Ballantyne
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Nienke Biermasz
  • Function : Author
Chuan Gao
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Sina Gharib
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José Haba-Rubio
  • Function : Author
Sami Heikkinen
  • Function : Author
Raphaël Heinzer
  • Function : Author
Georg Homuth
  • Function : Author
Pirjo Komulainen
  • Function : Author
Jingmin Liu
  • Function : Author
Kurt Lohman
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Reedik Mägi
  • Function : Author
Lisa Martin
  • Function : Author
Thomas Meitinger
  • Function : Author
Yuri Milaneschi
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Mike Nalls
  • Function : Author
Jeff O'Connell
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Olli Raitakari
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Alex Reiner
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Patrick Rensen
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Stephen Rich
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Till Roenneberg
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Jerome Rotter
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Pamela Schreiner
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James Shikany
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Stephen Sidney
  • Function : Author
Colleen Sitlani
  • Function : Author
Tamar Sofer
  • Function : Author
Konstantin Strauch
  • Function : Author
Morris Swertz
  • Function : Author
Kent Taylor
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Henry Völzke
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Robert Wallance
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Ko Willems van Dijk
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Alan Zonderman
  • Function : Author
Diane Becker
  • Function : Author
Paul Elliott
Tõnu Esko
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Hans Grabe
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Timo Lakka
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Brenda Penninx
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Lynne Wagenknecht
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Yong-Bing Xiang
  • Function : Author
Wei Zheng
Donna Arnett
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Tanika Kelly
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Stephen Kritchevsky
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Ruth Loos
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Bruce Psaty
  • Function : Author
Xiaofeng Zhu
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Ervin Fox
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Xiuqing Guo
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W. James Gauderman
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Kenneth Rice
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Charles Kooperberg
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Patricia Munroe
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Abstract

Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interactions in joint analyses, we identify 49 previously unreported lipid loci, and 10 additional previously unreported lipid loci in a restricted sample of European-ancestry cohorts. In addition, we identify new gene-sleep interactions for known lipid loci such as LPL and PCSK9 . The previously unreported lipid loci have a modest explained variance in lipid levels: most notable, gene-short-sleep interactions explain 4.25% of the variance in triglyceride level. Collectively, these findings contribute to our understanding of the biological mechanisms involved in sleep-associated adverse lipid profiles.
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Origin : Publication funded by an institution

Dates and versions

pasteur-03278561 , version 1 (05-07-2021)

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Attribution - CC BY 4.0

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Raymond Noordam, Maxime M. Bos, Heming Wang, Thomas W. Winkler, Amy R. Bentley, et al.. Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration. Nature Communications, 2019, 10 (1), pp.5121. ⟨10.1038/s41467-019-12958-0⟩. ⟨pasteur-03278561⟩

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