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Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration

Raymond Noordam 1, * Maxime Bos 1 Heming Wang 2 Thomas Winkler 3 Amy Bentley 4 Tuomas Kilpeläinen 5, 6 Paul de Vries 7 Yun Ju Sung 8 Karen Schwander 8 Brian Cade 2 Alisa Manning 9, 10 Hugues Aschard 11, 12 Michael Brown 7 Han Chen 7 Nora Franceschini 13 Solomon Musani 14 Melissa Richard 7 Dina Vojinovic 15 Stella Aslibekyan 16 Traci Bartz 17 Lisa de las Fuentes 8 Mary Feitosa 8 Andrea Horimoto 18 Marjan Ilkov 19 Minjung Kho 20 Aldi Kraja 8 Changwei Li 21 Elise Lim 22 Yongmei Liu 23 Dennis Mook-Kanamori 1 Tuomo Rankinen 24 Salman Tajuddin 4 Ashley van der Spek 15 Zhe Wang 7 Jonathan Marten 25 Vincent Laville 12 Maris Alver 26 Evangelos Evangelou 27, 28 Maria Graff 13 Meian He 29 Brigitte Kühnel 30 Leo-Pekka Lyytikäinen 31, 32 Pedro Marques-Vidal 33 Ilja Nolte 34 Nicholette Palmer Rainer Rauramaa Xiao-Ou Shu Harold Snieder 34 Stefan Weiss Wanqing Wen Lisa Yanek Correa Adolfo 14 Christie Ballantyne Larry Bielak 20 Nienke Biermasz Eric Boerwinkle 7 Niki Dimou 28 Gudny Eiriksdottir 19 Chuan Gao Sina Gharib Daniel Gottlieb 2, 10 José Haba-Rubio Tamara Harris 2 Sami Heikkinen Raphaël Heinzer James Hixson 7 Georg Homuth M. Arfan Ikram 15 Pirjo Komulainen Jose Krieger 18 Jiwon Lee 2 Jingmin Liu Kurt Lohman Annemarie Luik 15 Reedik Mägi 26 Lisa Martin Thomas Meitinger Andres Metspalu 26 Yuri Milaneschi Mike Nalls Jeff O'Connell Annette Peters 30 Patricia Peyser 20 Olli Raitakari Alex Reiner Patrick Rensen Treva Rice 8 Stephen Rich Till Roenneberg Jerome Rotter Pamela Schreiner James Shikany Stephen Sidney Mario Sims 14 Colleen Sitlani Tamar Sofer Konstantin Strauch Morris Swertz Kent Taylor André Uitterlinden 15 Cornelia van Duijn 15 Henry Völzke Melanie Waldenberger 30 Robert Wallance Ko Willems van Dijk Caizheng Yu 29 Alan Zonderman Diane Becker Paul Elliott 26 Tõnu Esko 26 Christian Gieger 30 Hans Grabe Timo Lakka Terho Lehtimäki 31, 32 Kari North 13 Brenda Penninx Peter Vollenweider 33 Lynne Wagenknecht Tangchun Wu 29 Yong-Bing Xiang Wei Zheng Donna Arnett Claude Bouchard 24 Michele Evans 4 Vilmundur Gudnason 19 Sharon Kardia 20 Tanika Kelly Stephen Kritchevsky Ruth Loos Alexandre Pereira 18 Mike Province 8 Bruce Psaty Charles Rotimi 4 Xiaofeng Zhu Najaf Amin 15 L. Adrienne Cupples 22 Myriam Fornage 7 Ervin Fox Xiuqing Guo W. James Gauderman Kenneth Rice Charles Kooperberg Patricia Munroe Ching-Ti Liu 22 Alanna Morrison 7 Dabeeru Rao 8 Diana van Heemst 1 Susan Redline 2, *
* Corresponding author
Abstract : Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interactions in joint analyses, we identify 49 previously unreported lipid loci, and 10 additional previously unreported lipid loci in a restricted sample of European-ancestry cohorts. In addition, we identify new gene-sleep interactions for known lipid loci such as LPL and PCSK9 . The previously unreported lipid loci have a modest explained variance in lipid levels: most notable, gene-short-sleep interactions explain 4.25% of the variance in triglyceride level. Collectively, these findings contribute to our understanding of the biological mechanisms involved in sleep-associated adverse lipid profiles.
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Raymond Noordam, Maxime Bos, Heming Wang, Thomas Winkler, Amy Bentley, et al.. Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration. Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.5121. ⟨10.1038/s41467-019-12958-0⟩. ⟨pasteur-03278561⟩

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