Journal articles

Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration

Raymond Noordam ^{1, *} Maxime M. Bos ¹ Heming Wang ² Thomas W. Winkler ³ Amy R. Bentley ⁴ Tuomas O. Kilpeläinen ^{5, 6} Paul S. de Vries ⁷ Yun Ju Sung ⁸ Karen Schwander ⁸ Brian E. Cade ² Alisa Manning ^{9, 10} Hugues Aschard ^{11, 12} Michael R. Brown ⁷ Han Chen ⁷ Nora Franceschini ¹³ Solomon K. Musani ¹⁴ Melissa Richard ⁷ Dina Vojinovic ¹⁵ Stella Aslibekyan ¹⁶ Traci M. Bartz ¹⁷ Lisa de Las Fuentes ⁸ Mary Feitosa ⁸ Andrea R. Horimoto ¹⁸ Marjan Ilkov ¹⁹ Minjung Kho ²⁰ Aldi Kraja ⁸ Changwei Li ²¹ Elise Lim ²² Yongmei Liu ²³ Dennis O. Mook-Kanamori ¹ Tuomo Rankinen ²⁴ Salman M. Tajuddin ⁴ Ashley van Der Spek ¹⁵ Zhe Wang ⁷ Jonathan Marten ²⁵ Vincent Laville ¹² Maris Alver ²⁶ Evangelos Evangelou ^{27, 28} Maria E. Graff ¹³ Meian He ²⁹ Brigitte Kühnel ³⁰ Leo-Pekka Lyytikäinen ^{31, 32} Pedro Marques-Vidal ³³ Ilja M. Nolte ³⁴ Nicholette Palmer Rainer Rauramaa Xiao-Ou Shu Harold Snieder ³⁴ Stefan Weiss Wanqing Wen Lisa Yanek Correa Adolfo ¹⁴ Christie Ballantyne Larry Bielak ²⁰ Nienke Biermasz Eric Boerwinkle ⁷ Niki Dimou ²⁸ Gudny Eiriksdottir ¹⁹ Chuan Gao Sina Gharib Daniel J. Gottlieb ^{2, 10} José Haba-Rubio Tamara Harris ² Sami Heikkinen Raphaël Heinzer James E. Hixson ⁷ Georg Homuth M. Arfan Ikram ¹⁵ Pirjo Komulainen Jose E. Krieger ¹⁸ Jiwon Lee ² Jingmin Liu Kurt Lohman Annemarie I. Luik ¹⁵ Reedik Mägi ²⁶ Lisa Martin Thomas Meitinger Andres Metspalu ²⁶ Yuri Milaneschi Mike Nalls Jeff O'Connell Annette Peters ³⁰ Patricia Peyser ²⁰ Olli Raitakari Alex Reiner Patrick Rensen Treva K. Rice ⁸ Stephen Rich Till Roenneberg Jerome Rotter Pamela Schreiner James Shikany Stephen Sidney Mario Sims ¹⁴ Colleen Sitlani Tamar Sofer Konstantin Strauch Morris Swertz Kent Taylor André G. Uitterlinden ¹⁵ Cornelia M. van Duijn ¹⁵ Henry Völzke Melanie Waldenberger ³⁰ Robert Wallance Ko Willems van Dijk Caizheng Yu ²⁹ Alan Zonderman Diane Becker Paul Elliott ²⁶ Tõnu Esko ²⁶ Christian Gieger ³⁰ Hans Grabe Timo Lakka Terho Lehtimäki ^{31, 32} Kari E. North ¹³ Brenda Penninx Peter Vollenweider ³³ Lynne Wagenknecht Tangchun Wu ²⁹ Yong-Bing Xiang Wei Zheng Donna Arnett Claude Bouchard ²⁴ Michele K. Evans ⁴ Vilmundur Gudnason ¹⁹ Sharon Kardia ²⁰ Tanika Kelly Stephen Kritchevsky Ruth Loos Alexandre C. Pereira ¹⁸ Mike Province ⁸ Bruce Psaty Charles Rotimi ⁴ Xiaofeng Zhu Najaf Amin ¹⁵ L. Adrienne Cupples ²² Myriam Fornage ⁷ Ervin Fox Xiuqing Guo W. James Gauderman Kenneth Rice Charles Kooperberg Patricia Munroe Ching-Ti Liu ²² Alanna C. Morrison ⁷ Dabeeru C. Rao ⁸ Diana van Heemst ¹ Susan Redline ^{2, *}

* Corresponding author

1 Leiden University Medical Center (LUMC)

2 BWH - Brigham & Women’s Hospital [Boston]

3 UR - Universität Regensburg

4 NIH - National Institutes of Health [Bethesda]

5 UCPH - University of Copenhagen = Københavns Universitet

6 MSSM - Icahn School of Medicine at Mount Sinai [New York]

7 UTHealth - The University of Texas Health Science Center at Houston

8 Washington University School of Medicine in St. Louis

9 Massachusetts General Hospital [Boston]

10 HMS - Harvard Medical School [Boston]

11 Harvard T.H. Chan School of Public Health

12 C3BI - Centre de Bioinformatique, Biostatistique et Biologie Intégrative

13 UNC - University of North Carolina [Chapel Hill]

14 UMMC - University of Mississippi Medical Center

15 Erasmus MC - Erasmus University Medical Center [Rotterdam]

16 UAB - University of Alabama at Birmingham [ Birmingham]

17 University of Washington [Seattle]

18 FMUSP - Universidade de São Paulo Medical School

19 IHA - Icelandic Heart Association [Kopavogur, Iceland]

20 University of Michigan [Ann Arbor]

21 University of Georgia [USA]

22 School of Public Health [Boston]

23 Wake Forest University

24 Pennington Biomedical Research Center

25 University of Edinburgh

26 University of Tartu

27 Imperial College London

28 University of Ioannina

29 HUST - Huazhong University of Science and Technology [Wuhan]

30 Helmholtz Zentrum München = German Research Center for Environmental Health

31 Fimlab Laboratories [Tampere, Finland]

32 University of Tampere [Finland]

33 Lausanne University Hospital

34 University of Groningen [Groningen]

Abstract : Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated adverse lipid profile, we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides). In the total study sample (discovery + replication) of 126,926 individuals from 5 different ancestry groups, when considering either long or short total sleep time interactions in joint analyses, we identify 49 previously unreported lipid loci, and 10 additional previously unreported lipid loci in a restricted sample of European-ancestry cohorts. In addition, we identify new gene-sleep interactions for known lipid loci such as LPL and PCSK9 . The previously unreported lipid loci have a modest explained variance in lipid levels: most notable, gene-short-sleep interactions explain 4.25% of the variance in triglyceride level. Collectively, these findings contribute to our understanding of the biological mechanisms involved in sleep-associated adverse lipid profiles.

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Genetics / Human genetics

Life Sciences [q-bio] / Santé publique et épidémiologie

Statistics [stat] / Methodology [stat.ME]

Statistics [stat] / Applications [stat.AP]

Computer Science [cs] / Bioinformatics [q-bio.QM]

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