Journal articles

Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

Amy R. Bentley ^{1, *} Yun J. Sung ² Michael R. Brown ³ Thomas W. Winkler ⁴ Aldi T. Kraja ² Ioanna Ntalla ⁵ Karen Schwander ² Daniel I. Chasman ^{6, 7} Elise Lim ⁸ Xuan Deng ⁸ Xiuqing Guo ⁹ Jingmin Liu ¹⁰ Yingchang Lu ¹¹ Ching-Yu Cheng ^{12, 13, 14} Xueling Sim ¹⁴ Dina Vojinovic ¹⁵ Jennifer E. Huffman ¹⁶ Solomon K. Musani ¹⁷ Changwei Li ¹⁸ Mary F. Feitosa ² Melissa A. Richard ³ Raymond Noordam ¹⁹ Jenna Baker ¹ Guanjie Chen ¹ Hugues Aschard ^{20, 21} Traci M. Bartz ²² Jingzhong Ding ²³ Rajkumar Dorajoo ²⁴ Alisa K. Manning ^{25, 7} Tuomo Rankinen ²⁶ Albert V. Smith ^{27, 28} Salman M. Tajuddin ¹ Wei Zhao ²⁹ Mariaelisa Graff ³⁰ Maris Alver ³¹ Mathilde Boissel ³² Jin Fang Chai ¹⁴ Xu Chen ³³ Jasmin Divers ³⁴ Evangelos Evangelou ^{35, 36} Chuan Gao ³⁴ Anuj Goel ³⁷ Yanick Hagemeijer ³⁸ Sarah E. Harris ¹⁶ Fernando P. Hartwig ^{39, 40} Meian He ⁴¹ Andrea R. V. R. Horimoto ⁴² Fang-Chi Hsu ³⁴ Yi-Jen Hung Anne Jackson Anuradhani Kasturiratne Pirjo Komulainen Brigitte Kühnel Karin Leander Keng-Hung Lin Jian'An Luan Leo-Pekka Lyytikäinen Nana Matoba Ilja Nolte Maik Pietzner Bram Prins Muhammad Riaz Antonietta Robino M. Abdullah Said ³⁸ Nicole Schupf Robert Scott Tamar Sofer ⁷ Alena Stancáková Fumihiko Takeuchi Bamidele Tayo Peter van Der Most Tibor Varga Tzung-Dau Wang Yajuan Wang Erin Ware Wanqing Wen Yong-Bing Xiang Lisa Yanek Weihua Zhang Jing Hua Zhao Adebowale Adeyemo ¹ Saima Afaq Najaf Amin ¹⁵ Marzyeh Amini Dan Arking Zorayr Arzumanyan ⁹ Tin Aung ^{12, 14} Christie Ballantyne R Graham Barr Lawrence F. Bielak ²⁹ Eric Boerwinkle ³ Erwin P. Bottinger ¹¹ Ulrich Broeckel Morris Brown ⁵ Brian Cade Archie Campbell Mickaël Canouil ³² Sabanayagam Charumathi ^{12, 13} Yii-Der Ida Chen ⁹ Kaare Christensen Maria Pina Concas John Connell Lisa de Las Fuentes ² H Janaka de Silva Paul S. de Vries ³ Ayo Doumatey ¹ Qing Duan Charles Eaton Ruben N. Eppinga ³⁸ Jessica Faul James S. Floyd ²² Nita Forouhi Terrence Forrester Yechiel Friedlander Ilaria Gandin He Gao ³⁵ Mohsen Ghanbari ¹⁵ Sina Gharib Bruna Gigante Franco Giulianini ⁶ Hans Grabe C. Charles Gu ² Tamara Harris Sami Heikkinen Chew-Kiat Heng Makoto Hirata James E. Hixson ³ M. Arfan Ikram ¹⁵ Yucheng Jia ⁹ Roby Joehanes Craig Johnson Jost Bruno Jonas Anne E. Justice ³⁰ Tomohiro Katsuya Chiea Chuen Khor ²⁴ Tuomas Kilpeläinen Woon-Puay Koh ¹⁴ Ivana Kolcic Charles Kooperberg Jose E. Krieger ⁴² Stephen Kritchevsky Michiaki Kubo Johanna Kuusisto Timo Lakka Carl D. Langefeld ³⁴ Claudia Langenberg Lenore Launer Benjamin Lehne Cora Lewis Yize Li ² Jingjing Liang Shiow Lin ² Ching-Ti Liu ⁸ Jianjun Liu ²⁴ Kiang Liu Marie Loh Kurt K. Lohman ³⁴ Tin Louie Anna Luzzi ⁹ Reedik Mägi ³¹ Anubha Mahajan ³⁷ Ani Manichaikul Colin Mckenzie Thomas Meitinger Andres Metspalu ³¹ Yuri Milaneschi Lili Milani ³¹ Karen Mohlke Yukihide Momozawa Andrew P. Morris ³⁷ Alison Murray Mike Nalls Matthias Nauck Christopher Nelson Kari E. North ³⁰ Jeffrey O'Connell Nicholette Palmer George Papanicolau Nancy L. Pedersen ³³ Annette Peters Patricia A. Peyser ²⁹ Ozren Polasek Neil Poulter Olli Raitakari Alex Reiner Frida Renström Treva K. Rice ² Stephen Rich Jennifer Robinson Lynda M. Rose ⁶ Frits Rosendaal Igor Rudan Carsten Schmidt Pamela Schreiner William Scott Peter Sever Yuan Shi ¹² Stephen Sidney Mario Sims ¹⁷ Jennifer A. Smith ²⁹ Harold Snieder John M. Starr ¹⁶ Konstantin Strauch Heather Stringham Nicholas Y. Q. Tan ¹² Hua Tang Kent D. Taylor ⁹ Yik Ying Teo ^{14, 24} Yih Chung Tham ¹² Henning Tiemeier ¹⁵ Stephen Turner André G. Uitterlinden ¹⁵ Diana van Heemst ¹⁹ Melanie Waldenberger Heming Wang ⁷ Lan Wang ⁸ Lihua Wang ² Wen Bin Wei Christine A. Williams ² Gregory Wilson Mary K. Wojczynski ² Jie Yao ⁹ Kristin Young ³⁰ Caizheng Yu ⁴¹ Jian-Min Yuan Jie Zhou ¹ Alan Zonderman Diane Becker Michael Boehnke Donald Bowden John C. Chambers ³⁵ Richard Cooper Ulf de Faire Ian J. Deary ¹⁶ Paul Elliott Tõnu Esko ³¹ Martin Farrall ³⁷ Paul Franks Barry Freedman Philippe Froguel ³² Paolo Gasparini Christian Gieger Bernardo L. Horta ³⁹ Jyh-Ming Jimmy Juang Yoichiro Kamatani Candace Kammerer Norihiro Kato Jaspal Kooner Markku Laakso Cathy Laurie I-Te Lee Terho Lehtimäki Patrik K. E. Magnusson ³³ Albertine Oldehinkel Brenda Penninx Alexandre C. Pereira ⁴² Rainer Rauramaa Susan Redline Nilesh Samani James Scott Xiao-Ou Shu Pim van Der Harst ³⁸ Lynne Wagenknecht Jun-Sing Wang Ya Xing Wang Nicholas Wareham Hugh Watkins ³⁷ David Weir Ananda Wickremasinghe Tangchun Wu ⁴¹ Eleftheria Zeggini Wei Zheng Claude Bouchard ²⁶ Michele K. Evans ¹ Vilmundur Gudnason ^{27, 28} Sharon L. R. Kardia ²⁹ Yongmei Liu Bruce M. Psaty ²² Paul M. Ridker ^{6, 7} Rob M. van Dam ¹⁴ Dennis Mook-Kanamori Myriam Fornage ³ Michael A. Province ² Tanika Kelly Ervin Fox Caroline Hayward ¹⁶ Cornelia M. van Duijn ¹⁵ E. Shyong Tai ¹⁴ Tien Yin Wong ^{12, 14} Ruth J. F. Loos ¹¹ Nora Franceschini ³⁰ Jerome I. Rotter ⁹ Xiaofeng Zhu ⁴³ Laura J. Bierut ² W. James Gauderman ⁴⁴ Kenneth Rice ²² Patricia B. Munroe ⁵ Alanna C. Morrison ³ Dabeeru C. Rao ² Charles N. Rotimi ^{1, *} L. Adrienne Cupples ^{8, *}

* Corresponding author

1 NIH - National Institutes of Health [Bethesda]

2 Washington University School of Medicine in St. Louis

3 UTHealth - The University of Texas Health Science Center at Houston

4 UR - Universität Regensburg

5 QMUL - Queen Mary University of London

6 Brigham and Women's Hospital [Boston]

7 HMS - Harvard Medical School [Boston]

8 School of Public Health [Boston]

9 LA BioMed - Los Angeles Biomedical Research Institute

10 FHCRC - Fred Hutchinson Cancer Research Center [Seattle]

11 MSSM - Icahn School of Medicine at Mount Sinai [New York]

12 SERI - Singapore Eye Research Institute [Singapore]

13 Duke-NUS Medical School [Singapore]

14 NUS - National University of Singapore

15 Erasmus MC - Erasmus University Medical Center [Rotterdam]

16 University of Edinburgh

17 UMMC - University of Mississippi Medical Center

18 University of Georgia [USA]

19 Leiden University Medical Center (LUMC)

20 C3BI - Centre de Bioinformatique, Biostatistique et Biologie Intégrative

21 Harvard T.H. Chan School of Public Health

22 University of Washington [Seattle]

23 Wake Forest University

24 GIS - Genome Institute of Singapore

25 Massachusetts General Hospital [Boston]

26 Pennington Biomedical Research Center

27 IHA - Icelandic Heart Association [Kopavogur, Iceland]

28 University of Iceland [Reykjavik]

29 University of Michigan [Ann Arbor]

30 UNC - University of North Carolina [Chapel Hill]

31 University of Tartu

32 EGENODIA (GI3M) - Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283

33 Karolinska Institutet [Stockholm]

34 Wake Forest School of Medicine [Winston-Salem]

35 Imperial College London

36 University of Ioannina

37 University of Oxford [Oxford]

38 University of Groningen [Groningen]

39 UFPel - Universidade Federal de Pelotas = Federal University of Pelotas

40 University of Bristol [Bristol]

41 HUST - Huazhong University of Science and Technology [Wuhan]

42 FMUSP - Universidade de São Paulo Medical School

43 Case Western Reserve University [Cleveland]

44 USC - University of Southern California

Abstract : The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Genetics / Human genetics

Life Sciences [q-bio] / Santé publique et épidémiologie

Statistics [stat] / Methodology [stat.ME]

Statistics [stat] / Applications [stat.AP]

Computer Science [cs] / Bioinformatics [q-bio.QM]

Complete list of metadata

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