Skip to Main content Skip to Navigation
Journal articles

Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids

Amy Bentley 1, * Yun Sung 2 Michael Brown 3 Thomas Winkler 4 Aldi Kraja 2 Ioanna Ntalla 5 Karen Schwander 2 Daniel Chasman 6, 7 Elise Lim 8 Xuan Deng 8 Xiuqing Guo 9 Jingmin Liu 10 Yingchang Lu 11 Ching-Yu Cheng 12, 13, 14 Xueling Sim 14 Dina Vojinovic 15 Jennifer Huffman 16 Solomon Musani 17 Changwei Li 18 Mary Feitosa 2 Melissa Richard 3 Raymond Noordam 19 Jenna Baker 1 Guanjie Chen 1 Hugues Aschard 20, 21 Traci Bartz 22 Jingzhong Ding 23 Rajkumar Dorajoo 24 Alisa Manning 25, 7 Tuomo Rankinen 26 Albert Smith 27, 28 Salman Tajuddin 1 Wei Zhao 29 Mariaelisa Graff 30 Maris Alver 31 Mathilde Boissel 32 Jin Fang Chai 14 Xu Chen 33 Jasmin Divers 34 Evangelos Evangelou 35, 36 Chuan Gao 34 Anuj Goel 37 Yanick Hagemeijer 38 Sarah Harris 16 Fernando Hartwig 39, 40 Meian He 41 Andrea Horimoto 42 Fang-Chi Hsu 34 Yi-Jen Hung Anne Jackson Anuradhani Kasturiratne Pirjo Komulainen Brigitte Kühnel Karin Leander Keng-Hung Lin Jian'An Luan Leo-Pekka Lyytikäinen Nana Matoba Ilja Nolte Maik Pietzner Bram Prins Muhammad Riaz Antonietta Robino M. Abdullah Said 38 Nicole Schupf Robert Scott Tamar Sofer 7 Alena Stancáková Fumihiko Takeuchi Bamidele Tayo Peter van der Most Tibor Varga Tzung-Dau Wang Yajuan Wang Erin Ware Wanqing Wen Yong-Bing Xiang Lisa Yanek Weihua Zhang Jing Hua Zhao Adebowale Adeyemo 1 Saima Afaq Najaf Amin 15 Marzyeh Amini Dan Arking Zorayr Arzumanyan 9 Tin Aung 12, 14 Christie Ballantyne R Graham Barr Lawrence Bielak 29 Eric Boerwinkle 3 Erwin Bottinger 11 Ulrich Broeckel Morris Brown 5 Brian Cade Archie Campbell Mickaël Canouil 32 Sabanayagam Charumathi 12, 13 Yii-Der Ida Chen 9 Kaare Christensen Maria Pina Concas John Connell Lisa de las Fuentes 2 H Janaka de Silva Paul de Vries 3 Ayo Doumatey 1 Qing Duan Charles Eaton Ruben Eppinga 38 Jessica Faul James Floyd 22 Nita Forouhi Terrence Forrester Yechiel Friedlander Ilaria Gandin He Gao 35 Mohsen Ghanbari 15 Sina Gharib Bruna Gigante Franco Giulianini 6 Hans Grabe C. Charles Gu 2 Tamara Harris Sami Heikkinen Chew-Kiat Heng Makoto Hirata James Hixson 3 M. Arfan Ikram 15 Yucheng Jia 9 Roby Joehanes Craig Johnson Jost Bruno Jonas Anne Justice 30 Tomohiro Katsuya Chiea Chuen Khor 24 Tuomas Kilpeläinen Woon-Puay Koh 14 Ivana Kolcic Charles Kooperberg Jose Krieger 42 Stephen Kritchevsky Michiaki Kubo Johanna Kuusisto Timo Lakka Carl Langefeld 34 Claudia Langenberg Lenore Launer Benjamin Lehne Cora Lewis Yize Li 2 Jingjing Liang Shiow Lin 2 Ching-Ti Liu 8 Jianjun Liu 24 Kiang Liu Marie Loh Kurt Lohman 34 Tin Louie Anna Luzzi 9 Reedik Mägi 31 Anubha Mahajan 37 Ani Manichaikul Colin Mckenzie Thomas Meitinger Andres Metspalu 31 Yuri Milaneschi Lili Milani 31 Karen Mohlke Yukihide Momozawa Andrew Morris 37 Alison Murray Mike Nalls Matthias Nauck Christopher Nelson Kari North 30 Jeffrey O'Connell Nicholette Palmer George Papanicolau Nancy Pedersen 33 Annette Peters Patricia Peyser 29 Ozren Polasek Neil Poulter Olli Raitakari Alex Reiner Frida Renström Treva Rice 2 Stephen Rich Jennifer Robinson Lynda Rose 6 Frits Rosendaal Igor Rudan Carsten Schmidt Pamela Schreiner William Scott Peter Sever Yuan Shi 12 Stephen Sidney Mario Sims 17 Jennifer Smith 29 Harold Snieder John Starr 16 Konstantin Strauch Heather Stringham Nicholas Tan 12 Hua Tang Kent Taylor 9 Yik Ying Teo 14, 24 Yih Chung Tham 12 Henning Tiemeier 15 Stephen Turner André Uitterlinden 15 Diana van Heemst 19 Melanie Waldenberger Heming Wang 7 Lan Wang 8 Lihua Wang 2 Wen Bin Wei Christine Williams 2 Gregory Wilson Mary Wojczynski 2 Jie Yao 9 Kristin Young 30 Caizheng Yu 41 Jian-Min Yuan Jie Zhou 1 Alan Zonderman Diane Becker Michael Boehnke Donald Bowden John Chambers 35 Richard Cooper Ulf de Faire Ian Deary 16 Paul Elliott Tõnu Esko 31 Martin Farrall 37 Paul Franks Barry Freedman Philippe Froguel 32 Paolo Gasparini Christian Gieger Bernardo Horta 39 Jyh-Ming Jimmy Juang Yoichiro Kamatani Candace Kammerer Norihiro Kato Jaspal Kooner Markku Laakso Cathy Laurie I-Te Lee Terho Lehtimäki Patrik Magnusson 33 Albertine Oldehinkel Brenda Penninx Alexandre Pereira 42 Rainer Rauramaa Susan Redline Nilesh Samani James Scott Xiao-Ou Shu Pim van der Harst 38 Lynne Wagenknecht Jun-Sing Wang Ya Xing Wang Nicholas Wareham Hugh Watkins 37 David Weir Ananda Wickremasinghe Tangchun Wu 41 Eleftheria Zeggini Wei Zheng Claude Bouchard 26 Michele Evans 1 Vilmundur Gudnason 27, 28 Sharon Kardia 29 Yongmei Liu Bruce Psaty 22 Paul Ridker 6, 7 Rob van Dam 14 Dennis Mook-Kanamori Myriam Fornage 3 Michael Province 2 Tanika Kelly Ervin Fox Caroline Hayward 16 Cornelia van Duijn 15 E. Shyong Tai 14 Tien Yin Wong 12, 14 Ruth Loos 11 Nora Franceschini 30 Jerome Rotter 9 Xiaofeng Zhu 43 Laura Bierut 2 W. James Gauderman 44 Kenneth Rice 22 Patricia Munroe 5 Alanna Morrison 3 Dabeeru Rao 2 Charles Rotimi 1, * L. Adrienne Cupples 8, *
* Corresponding author
Abstract : The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.
Complete list of metadata

https://hal-pasteur.archives-ouvertes.fr/pasteur-03278554
Contributor : Hugues Aschard <>
Submitted on : Monday, July 5, 2021 - 4:49:06 PM
Last modification on : Wednesday, July 7, 2021 - 3:27:52 AM

Links full text

Identifiers

Collections

Citation

Amy Bentley, Yun Sung, Michael Brown, Thomas Winkler, Aldi Kraja, et al.. Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. Nature Genetics, Nature Publishing Group, 2019, 51 (4), pp.636-648. ⟨10.1038/s41588-019-0378-y⟩. ⟨pasteur-03278554⟩

Share

Metrics

Record views

13