Making Sense of the Biodiversity and Virulence of Listeria monocytogenes
Abstract
Manuscript Highlights Listeria monocytogenes is a foodborne opportunistic bacterial pathogen Classical genetic approaches in reference strains allowed identification of core virulence genes Investigation of the species diversity of L. monocytogenes allowed uncovering hypoand hypervirulent strains and new virulence genes Hypervirulent strains are host-associated, whereas hypovirulent strains are associated with food-processing environments Accumulation of loss-of-function mutations in virulence pathways leads to niche restriction and obligate saprophytism
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