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Journal Articles Trends in Microbiology Year : 2002

The duality of virulence and transmissibility in Neisseria meningitidis

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Muhamed-Kheir Taha
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Ala-Eddine Deghmane
Aude Antignac
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Mireille Larribe
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Jean-Michel Alonso
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Abstract

Neisseria meningitidis is a commensal bacterium of the human nasopharynx that occasionally provokes invasive disease. Carriage strains of N. meningitidis are heterogeneous, more frequent in nature and are transmitted among carriers. Disease is not a part of this transmission cycle and is caused by virulent strains. N. meningitidis is highly variable and variants that are modified in their virulence and/or transmissibility are continually generated. These events probably occur frequently, thus explaining not only the heterogeneous nature of meningococcal populations in carriers but probably also the evolutionary success of this human-restricted bacterium.

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pasteur-03262265 , version 1 (16-06-2021)

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Muhamed-Kheir Taha, Ala-Eddine Deghmane, Aude Antignac, Maria Leticia Zarantonelli, Mireille Larribe, et al.. The duality of virulence and transmissibility in Neisseria meningitidis. Trends in Microbiology, 2002, 10 (8), pp.376-382. ⟨10.1016/s0966-842x(02)02402-2⟩. ⟨pasteur-03262265⟩

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