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Comparison of whole-cell versus acellular pertussis vaccine effectiveness in school clusters of pertussis, France, 2013

Abstract : Objectives and method.-We conducted a prospective study in 2013 to compare the whole-cell versus acellular pertussis vaccines effectiveness and duration of protection, following the occurrence of pertussis clusters. Results.-During seven school outbreaks, we identified 102 clinical pertussis cases, including 10 cases biologically confirmed by Bordetella pertussis specific PCR, among a cohort of 305 children in 2nd to 6th grade. The risk of pertussis when vaccinated with an acellular vaccine alone was 1.6 (RR = 1.6; 95% CI = 1.1-2.5) times higher than when vaccinated with a whole-cell vaccine or using a combined schedule. Conclusions.-The limited duration of protection conferred by the acellular vaccine reinforces the 2013 introduction of the pertussis booster at six years old.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-03257292
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Submitted on : Thursday, June 10, 2021 - 6:37:05 PM
Last modification on : Thursday, April 7, 2022 - 10:10:54 AM

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Emmanuel Belchior, Sophie Guillot, I. Poujol, A. Thabuis, L. Chouin, et al.. Comparison of whole-cell versus acellular pertussis vaccine effectiveness in school clusters of pertussis, France, 2013. Médecine et Maladies Infectieuses, Elsevier Masson, 2020, 50 (7), pp.617 - 619. ⟨10.1016/j.medmal.2020.07.004⟩. ⟨pasteur-03257292⟩

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