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Antibody Neutralization of HIV-1 Crossing the Blood-Brain Barrier

Abstract : HIV-1 can cross the blood-brain barrier (BBB) to penetrate the brain and infect target cells, causing neurocognitive disorders as a result of neuroinflammation and brain damage. The HIV-1 envelope spike gp160 is partially required for viral transcytosis across the BBB endothelium. But do antibodies developing in infected individuals and targeting the HIV-1 gp160 glycoproteins block HIV-1 transcytosis through the BBB? We addressed this issue and discovered that anti-gp160 antibodies do not block HIV-1 transport; instead, free viruses and those in complex with antibodies can transit across BBB endothelial cells. Importantly, we found that only neutralizing antibodies could inhibit posttranscytosis viral infectivity, highlighting their ability to protect susceptible brain cells from HIV-1 infection.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-03246667
Contributor : Philippe Afonso Connect in order to contact the contributor
Submitted on : Wednesday, June 2, 2021 - 2:51:43 PM
Last modification on : Monday, November 29, 2021 - 2:30:02 PM
Long-term archiving on: : Friday, September 3, 2021 - 7:28:59 PM

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mBio.02424-20.pdf
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Distributed under a Creative Commons Attribution 4.0 International License

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Valérie Lorin, Anne Danckaert, Françoise Porrot, Olivier Schwartz, Philippe Afonso, et al.. Antibody Neutralization of HIV-1 Crossing the Blood-Brain Barrier. mBio, American Society for Microbiology, 2020, 11 (5), pp.e02424-20. ⟨10.1128/mBio.02424-20⟩. ⟨pasteur-03246667⟩

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