Antibody Neutralization of HIV-1 Crossing the Blood-Brain Barrier - Institut Pasteur Access content directly
Journal Articles mBio Year : 2020

Antibody Neutralization of HIV-1 Crossing the Blood-Brain Barrier

Abstract

HIV-1 can cross the blood-brain barrier (BBB) to penetrate the brain and infect target cells, causing neurocognitive disorders as a result of neuroinflammation and brain damage. The HIV-1 envelope spike gp160 is partially required for viral transcytosis across the BBB endothelium. But do antibodies developing in infected individuals and targeting the HIV-1 gp160 glycoproteins block HIV-1 transcytosis through the BBB? We addressed this issue and discovered that anti-gp160 antibodies do not block HIV-1 transport; instead, free viruses and those in complex with antibodies can transit across BBB endothelial cells. Importantly, we found that only neutralizing antibodies could inhibit posttranscytosis viral infectivity, highlighting their ability to protect susceptible brain cells from HIV-1 infection.

Domains

Immunology
Fichier principal
Vignette du fichier
mBio.02424-20.pdf (1.74 Mo) Télécharger le fichier
Origin : Publication funded by an institution

Dates and versions

pasteur-03246667 , version 1 (02-06-2021)

Licence

Attribution - CC BY 4.0

Identifiers

Cite

Valérie Lorin, Anne Danckaert, Françoise Porrot, Olivier Schwartz, Philippe Afonso, et al.. Antibody Neutralization of HIV-1 Crossing the Blood-Brain Barrier. mBio, 2020, 11 (5), pp.e02424-20. ⟨10.1128/mBio.02424-20⟩. ⟨pasteur-03246667⟩
27 View
30 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More