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Journal articles
Antibody Neutralization of HIV-1 Crossing the Blood-Brain Barrier
Abstract : HIV-1 can cross the blood-brain barrier (BBB) to penetrate the brain and infect target cells, causing neurocognitive disorders as a result of neuroinflammation and brain damage. The HIV-1 envelope spike gp160 is partially required for viral transcytosis across the BBB endothelium. But do antibodies developing in infected individuals and targeting the HIV-1 gp160 glycoproteins block HIV-1 transcytosis through the BBB? We addressed this issue and discovered that anti-gp160 antibodies do not block HIV-1 transport; instead, free viruses and those in complex with antibodies can transit across BBB endothelial cells. Importantly, we found that only neutralizing antibodies could inhibit posttranscytosis viral infectivity, highlighting their ability to protect susceptible brain cells from HIV-1 infection.
https://hal-pasteur.archives-ouvertes.fr/pasteur-03246667
Contributor : Philippe Afonso <>
Submitted on : Wednesday, June 2, 2021 - 2:51:43 PM
Last modification on : Wednesday, June 16, 2021 - 2:56:43 PM
Contributor : Philippe Afonso <>
Submitted on : Wednesday, June 2, 2021 - 2:51:43 PM
Last modification on : Wednesday, June 16, 2021 - 2:56:43 PM
File
mBio.02424-20.pdf
Publication funded by an institution
Licence
Distributed under a Creative Commons Attribution 4.0 International License