HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Une re-vue de la sénescence cellulaire : Ami ou ennemi de la promotion tumorale ?

Abstract : Cellular senescence, like apoptosis, is now widely accepted as a potent tumor suppressor mechanism operating in normal mitotic mammalian cells. Originally, it was identified as a process that limits the replicative lifespan of primary human cells in culture because of telomere attrition and was therefore termed "replicative" senescence (RS). However, previous findings have demonstrated that a phenotype indistinguishable from replicative senescence, collectively called "stress-induced premature" senescence (SIPS), can be induced without extensive cell division in normal as well as cancer cells by a variety of stresses and signaling imbalances. Recent developments have also indicated that, despite their tumor-suppressive capacity, senescent cells themselves could produce neoplastic cells under certain circumstances and promote the growth of preneoplastic cells, raising the possibility that senescence might function as a biological "Trojan" horse. Here, we take a snapshot of the progress in understanding the causes and consequences of cellular senescence in vitro and in vivo.
Document type :
Journal articles
Complete list of metadata

https://hal-pasteur.archives-ouvertes.fr/pasteur-03236210
Contributor : Samia Cheriet Rauline Connect in order to contact the contributor
Submitted on : Wednesday, May 26, 2021 - 10:42:59 AM
Last modification on : Thursday, April 7, 2022 - 10:10:29 AM
Long-term archiving on: : Friday, August 27, 2021 - 6:46:00 PM

File

medsci2009252p153.pdf
Publisher files allowed on an open archive

Licence

Copyright

Identifiers

Collections

Citation

Oliver Bischof, Anne Dejean, Pascal Pineau. Une re-vue de la sénescence cellulaire : Ami ou ennemi de la promotion tumorale ?. médecine/sciences, EDP Sciences, 2009, 25 (2), pp.153-160. ⟨10.1051/medsci/2009252153⟩. ⟨pasteur-03236210⟩

Share

Metrics

Record views

13

Files downloads

19