Skip to Main content Skip to Navigation
Journal articles

MicroRNAs and lncRNAs in senescence: A re‐view

Abstract : Cellular senescence is a stress response to a variety of extrinsic and intrinsic insults that cause genomic or epigenomic perturbations. It is now widely recognized as a potent tumor suppressor mechanism as well as a biological process impacting aging and organismal development. Like other cell fate decisions, senescence is executed and maintained by an intricate network of transcription factors (TFs), chromatin modifiers, and noncoding RNAs (ncRNAs). Altogether, these factors cooperate to implement the gene expression program that initiates and sustains the senescent phenotype. In the context of senescence, microRNAs (miRs) and long ncRNAs have been found to play regulatory roles at both the transcriptional and post-transcriptional levels. In this review, we discuss recent developments in the field and point toward future research directions to gain a better understanding of ncRNAs in senescence.
Document type :
Journal articles
Complete list of metadata

https://hal-pasteur.archives-ouvertes.fr/pasteur-03234975
Contributor : Samia Cheriet Rauline Connect in order to contact the contributor
Submitted on : Tuesday, May 25, 2021 - 3:48:21 PM
Last modification on : Tuesday, October 19, 2021 - 10:28:46 PM
Long-term archiving on: : Thursday, August 26, 2021 - 8:18:48 PM

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Oliver Bischof, Ricardo Iván Martínez-Zamudio. MicroRNAs and lncRNAs in senescence: A re‐view. IUBMB Life, Wiley, 2015, 67 (4), pp.255-267. ⟨10.1002/iub.1373⟩. ⟨pasteur-03234975⟩

Share

Metrics

Record views

20

Files downloads

39