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Prevalence of anti-R-13 antibodies in human Trypanosoma cruzi infection

Abstract : Infection with Trypanosoma cruzi develops in three phases: acute, indeterminate or asymptomatic, and chronic phase (with cardiac or digestive manifestations). Moreover, transmission may occur from infected mothers to newborn, the so-called congenital form. In the present study, humoral responses against T. cruzi total extract and against the 13 amino acid peptide named R-13 derived from the parasite ribosomal P protein, previously described as a possible marker of chronic Chagas heart disease, were determined in chagasic patients and in blood bank donors from endemic areas. While in sera from acute phase, only IgM anti-T.cruzi response was observed, both IgM and IgG anti-T. cruzi antibodies were detected in sera from congenitally infected newborns. The percentage of positive response in sera from blood bank donors was relatively high in endemic regions. Antibodies against the R-13 peptide were present in a large proportion of cardiac chagasic patients but were totally lacking in patients with digestive form of Chagas' disease. Furthermore, anti-R-13 positive responses were detected in congenitally infected newborns.
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Christine Aznar, Pablo Lopez-Bergami, Silvia Brandariz, Christine Chevalier, Pascale Liegeard, et al.. Prevalence of anti-R-13 antibodies in human Trypanosoma cruzi infection. FEMS Immunology and Medical Microbiology, Wiley-Blackwell: No OnlineOpen, 1995, 12 (3-4), pp.231-237. ⟨10.1111/j.1574-695X.1995.tb00197.x⟩. ⟨pasteur-03229841⟩



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