Skip to Main content Skip to Navigation
Journal articles

Invasive Infections with Nannizziopsis obscura Species Complex in 9 Patients from West Africa, France, 2004–20201

Abstract : Nine new human invasive infections caused by the keratinophilic fungi Nannizziopsis obscura have been reported in France since 2004. The patients had variable clinical manifestations, had frequent dissemination, were mainly T-cell immunocompromised, and all originated from sub-Saharan West Africa. Before collection of the isolates, the etiologies of these infections were often misidentified, underscoring the extent of microscopic and cultural polymorphisms. All isolates but 1 had low MICs for the 8 antifungal drugs tested. When treated, patients received mainly azole therapy. Two of 7 patients with a known outcome died. We performed multilocus sequence analysis of N. obscura clinical strains and several strains of Nannizziopsis spp. isolated from reptiles. The human strains were clearly differentiated from the animal strains. N. obscura might be endemic to West Africa and responsible for undetected infections, which might become reactivated when immunosuppression occurs. N. obscura infection is probably underestimated because only sequencing enables proper identification.
Document type :
Journal articles
Complete list of metadata

https://hal-pasteur.archives-ouvertes.fr/pasteur-03222568
Contributor : Christèle Auguste <>
Submitted on : Monday, May 10, 2021 - 12:29:36 PM
Last modification on : Wednesday, June 2, 2021 - 4:26:14 PM
Long-term archiving on: : Wednesday, August 11, 2021 - 7:20:53 PM

File

Garcia-Hermoso2020EID.pdf
Publisher files allowed on an open archive

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Citation

Dea Garcia-Hermoso, Samia Hamane, Arnaud Fekkar, Arnaud Jabet, Blandine Denis, et al.. Invasive Infections with Nannizziopsis obscura Species Complex in 9 Patients from West Africa, France, 2004–20201. Emerging Infectious Diseases, Centers for Disease Control and Prevention, 2020, 26 (9), ⟨10.3201/eid2609.200276⟩. ⟨pasteur-03222568⟩

Share

Metrics

Record views

48

Files downloads

100