The Spatial Heterogeneity of the Gut Limits Predation and Fosters Coexistence of Bacteria and Bacteriophages - Archive ouverte HAL Access content directly
Journal Articles Cell Host & Microbe Year : 2020

The Spatial Heterogeneity of the Gut Limits Predation and Fosters Coexistence of Bacteria and Bacteriophages

(1, 2) , (1, 3) , (1, 4) , (1) , (5) , (6) , (7) , (6, 8) , (1) , (1, 3)
1
2
3
4
5
6
7
8

Abstract

The ecological dynamics underlying the coexistence between antagonistic populations of bacteria and their viruses, bacteriophages (phages), in the mammalian gut microbiota remain poorly understood. We challenged a murine synthetic bacterial community with phages to study the factors allowing phages-bacteria coexistence. Coexistence was not dependent on the development of phage-resistant clones nor on the ability of phages to extend their host range. Instead, our data suggest that phage-inaccessible sites in the mucosa serve as a spatial refuge for bacteria. From there, bacteria disseminate in the gut lumen where they are predated by luminal phages fostering the presence of intestinal phage populations. The heterogeneous biogeography of microbes contributes to the long-term coexistence of phages with phage-susceptible bacteria. This observation could explain the persistence of intestinal phages in humans as well as the low efficiency of oral phage therapy against enteric pathogens in animal models and clinical trials.
Fichier principal
Vignette du fichier
Lourenço-Revfinal.pdf (652.5 Ko) Télécharger le fichier
Vignette du fichier
Lourenço-Supp.pdf (1.81 Mo) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

pasteur-03161210 , version 1 (05-03-2021)

Licence

Attribution - NonCommercial - NoDerivatives - CC BY 4.0

Identifiers

Cite

Marta Lourenço, Lorenzo Chaffringeon, Quentin Lamy-Besnier, Thierry Pedron, Pascal Campagne, et al.. The Spatial Heterogeneity of the Gut Limits Predation and Fosters Coexistence of Bacteria and Bacteriophages. Cell Host & Microbe, 2020, 28 (3), pp.390-401.e5. ⟨10.1016/j.chom.2020.06.002⟩. ⟨pasteur-03161210⟩
97 View
100 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More