Bioengineering of Bordetella pertussis Adenylate Cyclase Toxin for Vaccine Development and Other Biotechnological Purposes - Archive ouverte HAL Access content directly
Journal Articles Toxins Year : 2021

Bioengineering of Bordetella pertussis Adenylate Cyclase Toxin for Vaccine Development and Other Biotechnological Purposes

(1)
1

Abstract

The adenylate cyclase toxin, CyaA, is one of the key virulent factors produced by Bordetella pertussis, the causative agent of whooping cough. This toxin primarily targets innate immunity to facilitate bacterial colonization of the respiratory tract. CyaA exhibits several remarkable characteristics that have been exploited for various applications in vaccinology and other biotechnological purposes. CyaA has been engineered as a potent vaccine vehicle to deliver antigens into antigen-presenting cells, while the adenylate cyclase catalytic domain has been used to design a robust genetic assay for monitoring protein-protein interactions in bacteria. These two biotechnological applications are briefly summarized in this chapter.
Fichier principal
Vignette du fichier
toxins-13-00083-v2.pdf (1.74 Mo) Télécharger le fichier
Origin : Publication funded by an institution

Dates and versions

pasteur-03137937 , version 1 (10-02-2021)

Licence

Attribution - CC BY 4.0

Identifiers

Cite

Daniel Ladant. Bioengineering of Bordetella pertussis Adenylate Cyclase Toxin for Vaccine Development and Other Biotechnological Purposes. Toxins, 2021, 13 (2), pp.83. ⟨10.3390/toxins13020083⟩. ⟨pasteur-03137937⟩

Collections

PASTEUR CNRS
21 View
32 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More