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Abstract : The adenylate cyclase toxin, CyaA, is one of the key virulent factors produced by Bordetella pertussis, the causative agent of whooping cough. This toxin primarily targets innate immunity to facilitate bacterial colonization of the respiratory tract. CyaA exhibits several remarkable characteristics that have been exploited for various applications in vaccinology and other biotechnological purposes. CyaA has been engineered as a potent vaccine vehicle to deliver antigens into antigen-presenting cells, while the adenylate cyclase catalytic domain has been used to design a robust genetic assay for monitoring protein-protein interactions in bacteria. These two biotechnological applications are briefly summarized in this chapter.
https://hal-pasteur.archives-ouvertes.fr/pasteur-03137937 Contributor : Bénédicte BENEDICConnect in order to contact the contributor Submitted on : Wednesday, February 10, 2021 - 5:56:31 PM Last modification on : Thursday, April 7, 2022 - 10:10:44 AM Long-term archiving on: : Tuesday, May 11, 2021 - 9:06:10 PM
Daniel Ladant. Bioengineering of Bordetella pertussis Adenylate Cyclase Toxin for Vaccine Development and Other Biotechnological Purposes. Toxins, MDPI, 2021, 13 (2), pp.83. ⟨10.3390/toxins13020083⟩. ⟨pasteur-03137937⟩