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Journal articles
Conformations of immunoglobulin hypervariable regions
Cyrus Chothia
1, 2
Arthur Lesk
1, 3
Anna Tramontano
3
Michael Levitt
4, 1, 5
Sandra Smith-Gill
6
Gillian Air
7
Steven Sheriff
6
Eduardo Padlan
6
David Davies
6
William Tulip
8
Peter Colman
8
Silvia Spinelli
9
Pedro Alzari
9
Roberto Poljak
9
Cyrus Chothia 1, 2
Author
Arthur Lesk 1, 3
Author
Anna Tramontano 3
Author
Michael Levitt 4, 1, 5
Author
Pedro Alzari 9
Author
Roberto Poljak 9
Author
1
LMB - MRC Laboratory of Molecular Biology [Cambridge, UK] (Cambridge Biomedical Campus, Francis Crick Ave, Trumpington, Cambridge CB2 0QH, Royaume-Uni
- United Kingdom)
- CAM - University of Cambridge [UK] (The Old Schools, Trinity Lane, Cambridge CB2 1TN - United Kingdom)
- Medical Research Council (United Kingdom)
2
UCL - University College of London [London] (Gower Street, London WC1E 6BT - United Kingdom)
3
EMBL - European Molecular Biology Laboratory [Heidelberg] (Meyerhofstraße 1, 69117 Heidelberg, Germany - Germany)
4
Department of Structural Biology [Stanford] (Stanford University, Stanford Medicine, 299 Campus Dr. West Stanford, CA 94305-5126 - United States)
- Stanford Medicine (Stanford University - United States)
- Stanford University (450 Serra Mall, Stanford, CA 94305-2004 - United States)
5
Stanford University (450 Serra Mall, Stanford, CA 94305-2004 - United States)
6
NIH - National Institutes of Health [Bethesda] (9000 Rockville Pike, Bethesda, Maryland 20892 - United States)
7
UA - University of Alabama [Tuscaloosa] (Tuscaloosa, AL 35487 - United States)
8
CSIRO Energy Technology - Commonwealth Scientific and Industrial Research Organisation Energy Technology (CSIRO Energy Technology - Newcastle Steel River Estate 10 Murray Dwyer Circuit Mayfield West NSW 2304 Australia - Australia)
- CSIRO - Commonwealth Scientific and Industrial Research Organisation [Canberra] (GPO Box 1700, Canberra ACT 2600 - Australia)
9
Immunologie structurale (25-28 rue du Docteur Roux F-75724 Paris Cedex 15 - France)
- Institut Pasteur [Paris] (25-28, rue du docteur Roux, 75724 Paris cedex 15 - France)
- CNRS - Centre National de la Recherche Scientifique : URA2185 / URA1961 / URA359 / URA385 (France)
Abstract : On the basis of comparative studies of known antibody structures and sequences it has been argued that there is a small repertoire of main-chain conformations for at least five of the six hypervariable regions of antibodies, and that the particular conformation adopted is determined by a few key conserved residues. These hypotheses are now supported by reasonably successful predictions of the structures of most hypervariable regions of various antibodies, as revealed by comparison with their subsequently determined structures.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-03136436
Contributor : Marie de Tarragon <>
Submitted on : Tuesday, February 9, 2021 - 4:59:02 PM
Last modification on : Friday, April 2, 2021 - 11:36:00 AM
Contributor : Marie de Tarragon <>
Submitted on : Tuesday, February 9, 2021 - 4:59:02 PM
Last modification on : Friday, April 2, 2021 - 11:36:00 AM
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- HAL Id : pasteur-03136436, version 1
- DOI : 10.1038/342877a0
- PUBMED : 2687698
Citation
Cyrus Chothia, Arthur Lesk, Anna Tramontano, Michael Levitt, Sandra Smith-Gill, et al.. Conformations of immunoglobulin hypervariable regions. Nature, Nature Publishing Group, 1989, 342 (6252), pp.877-883. ⟨10.1038/342877a0⟩. ⟨pasteur-03136436⟩
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