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OXA-244-Producing Escherichia coli Isolates, a Challenge for Clinical Microbiology Laboratories

Abstract : OXA-244 is a single-point-mutant derivative of OXA-48 displaying reduced carbapenemase activity. Here, we report the microbiological features of seven OXA-244-producing Escherichia coli isolates. Only one isolate grew on ChromID Carba Smart medium (bioMérieux), but six of the seven isolates grew on ChromID extended-spectrum-β-lactamase (ESBL) medium (bioMérieux), as they coproduced an ESBL and/or a plasmid-encoded cephalosporinase. The production of a carbapenemase was detected in 57.1%, 71.4%, 71.4%, and 100% of the E. coli isolates using the Carba NP test, the Rapidec Carba NP test (bioMérieux), a matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) hydrolysis assay (Bruker), and the OXA-48 K-SeT assay (Coris BioConcept), respectively. Our results indicate that OXA-244-producing E. coli isolates are difficult to detect, which may lead to their silent spread.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-03107799
Contributor : Reine Bouyssie <>
Submitted on : Tuesday, January 12, 2021 - 7:32:35 PM
Last modification on : Monday, March 29, 2021 - 2:46:45 PM
Long-term archiving on: : Tuesday, April 13, 2021 - 6:58:57 PM

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Yannick Hoyos-Mallecot, Thierry Naas, Rémy Bonnin, Rafael Patino, Philippe Glaser, et al.. OXA-244-Producing Escherichia coli Isolates, a Challenge for Clinical Microbiology Laboratories. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2017, 61 (9), ⟨10.1128/AAC.00818-17⟩. ⟨pasteur-03107799⟩

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