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Journal Articles Journal of Structural Biology Year : 2019

The crystal structure of Rv2991 from Mycobacterium tuberculosis: An F420 binding protein with unknown function

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Abstract

The crystal structure of the conserved hypothetical protein Rv2991 from Mycobacterium tuberculosis has been solved by SAD using seleno-methionine substituted protein. The dimeric biological assembly and the sequence and fold conservation are typical of F420 cofactor binding enzymes. Despite Rv2991 still being of unknown function, sequence and structural comparison with similar proteins enable a role to be proposed for its C-terminal stretch of residues in recognizing and orienting the substrate. In addition, the C-terminus is involved in both protein folding and determining the size of the active site cavity.

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pasteur-03095980 , version 1 (04-01-2021)

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Stefano Benini, Ahmed Haouz, Florence Proux, Pedro Alzari, Keith Wilson. The crystal structure of Rv2991 from Mycobacterium tuberculosis: An F420 binding protein with unknown function. Journal of Structural Biology, 2019, 206 (2), pp.216-224. ⟨10.1016/j.jsb.2019.03.006⟩. ⟨pasteur-03095980⟩

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