Skip to Main content Skip to Navigation
New interface
Journal articles

Host genetic susceptibility to viral infections: the role of type I interferon induction

Abstract : The innate immune response is the major front line of defense against viral infections. It involves hundreds of genes with antiviral properties which expression is induced by type I interferons (IFNs) and are therefore called interferon stimulated genes (ISGs). Type I IFNs are produced after viral recognition by pathogen recognition receptors, which trigger a cascade of activation events. Human and mouse studies have shown that defective type I IFNs induction may hamper the ability to control viral infections. In humans, moderate to high-effect variants have been identified in individuals with particularly severe complications following viral infection. In mice, functional studies using knock-out alleles have revealed the specific role of most genes of the IFN pathway. Here, we review the role of the molecular partners of the type I IFNs induction pathway and their implication in the control of viral infections and of their complications.
Document type :
Journal articles
Complete list of metadata
Contributor : Xavier MONTAGUTELLI Connect in order to contact the contributor
Submitted on : Thursday, December 3, 2020 - 9:06:50 PM
Last modification on : Thursday, April 7, 2022 - 10:10:44 AM
Long-term archiving on: : Thursday, March 4, 2021 - 8:00:08 PM


Bourdon GAI (1).pdf
Files produced by the author(s)


Distributed under a Creative Commons Attribution - NonCommercial 4.0 International License




Marie Bourdon, Caroline Manet, Xavier Montagutelli. Host genetic susceptibility to viral infections: the role of type I interferon induction. Genes and Immunity, 2020, ⟨10.1038/s41435-020-00116-2⟩. ⟨pasteur-03017356⟩



Record views


Files downloads