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Journal Articles Science Year : 2020

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

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Qian Zhang
Liis Haljasmägi
Pärt Peterson
Benedetta Bigio
Rui Yang
Alexandre Bolze
David Smadja
Diederik van de Beek
Filomeen Haerynck
Kai Kisand

Abstract

Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-ω (IFN-ω) (13 patients), against the 13 types of IFN-α (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.
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Dates and versions

pasteur-02958871 , version 1 (06-10-2020)

Licence

Attribution - CC BY 4.0

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Paul Bastard, Lindsey B. Rosen, Qian Zhang, Eleftherios Michailidis, Hans-Heinrich Hoffmann, et al.. Autoantibodies against type I IFNs in patients with life-threatening COVID-19. Science, 2020, 370 (6515), pp.eabd4585. ⟨10.1126/science.abd4585⟩. ⟨pasteur-02958871⟩
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