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Journal articles

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Paul Bastard ^{1, 2, *} Lindsey B. Rosen ³ Qian Zhang ² Eleftherios Michailidis ² Hans-Heinrich Hoffmann ² yu Zhang ³ Karim Dorgham ⁴ Quentin Philippot ¹ Jérémie Rosain ¹ Vivien Béziat ^{1, 2} Jérémy Manry ¹ Elana Shaw ³ Liis Haljasmägi ⁵ Pärt Peterson ⁵ Lazaro Lorenzo ¹ Lucy Bizien ¹ Sophie Trouillet-Assant ^{6, 7} Kerry Dobbs ³ Adriana Almeida de Jesus ³ Alexandre Belot ^{7, 8, 9} Anne Kallaste ¹⁰ Emilie Catherinot ¹¹ yacine Tandjaoui-Lambiotte ^{12, 13} Jeremie Le Pen ² Gaspard Kerner ¹ Benedetta Bigio ² yoann Seeleuthner ¹ Rui yang ² Alexandre Bolze ¹⁴ András N. Spaan ^{2, 15} Ottavia M. Delmonte ³ Michael S. Abers ³ Alessandro Aiuti ^{16, 17} Giorgio Casari ^{16, 17} Vito Lampasona ^{16, 17} Lorenzo Piemonti ^{16, 17} Fabio Ciceri ^{16, 17} Kaya Bilguvar ¹⁸ Richard P. Lifton ^{18, 2} Marc Vasse ¹¹ David Smadja ¹⁹ Mélanie Migaud ¹ Jérome Hadjadj ²⁰ Benjamin Terrier ^{21, 22} Darragh Duffy ²³ Lluis Quintana-Murci ^{24, 25} Diederik van de Beek ²⁶ Lucie Roussel ²⁷ Donald C. Vinh ²⁷ Stuart G. Tangye ^{28, 29} Filomeen Haerynck ³⁰ David Dalmau ^{31, 32} Javier Martinez-Picado ^{33, 34, 35} Petter Brodin ^{36, 37} Michel C. Nussenzweig ^{2, 38} Stéphanie Boisson-Dupuis ^{1, 2} Carlos Rodríguez-Gallego ^{39, 40} Guillaume Vogt ⁴¹ Trine H. Mogensen ^{42, 43} Andrew J. Oler ³ Jingwen Gu ³ Peter D. Burbelo ⁴⁴ Jeffrey Cohen ³ Andrea Biondi ^{45, 46} Laura Rachele Bettini ^{45, 46} Mariella d'Angio ^{45, 46} Paolo Bonfanti ^{47, 45} Patrick Rossignol ⁴⁸ Julien Mayaux ⁴⁹ Frédéric Rieux-Laucat ²⁰ Eystein S. Husebye ^{50, 51, 36} Francesca Fusco ⁵² Matilde Valeria Ursini ⁵² Luisa Imberti ⁵³ Alessandra Sottini ⁵³ Simone Paghera ⁵³ Eugenia Quiros-Roldan ^{54, 53} Camillo Rossi ⁵³ Riccardo Castagnoli ^{55, 56} Daniela Montagna ^{56, 55} Amelia Licari ^{55, 56} Gian Luigi Marseglia ^{55, 56} Xavier Duval ^{57, 58, 59, 60} Jade Ghosn ^{59, 58} John S. Tsang ³ Raphaela Goldbach-Mansky ³ Kai Kisand ⁵ Michail S. Lionakis ³ Anne Puel ^{1, 2} Shen-ying Zhang ^{1, 2} Steven M. Holland ³ Guy Gorochov ^{4, 61} Emmanuelle Jouanguy ^{1, 2} Charles M. Rice ² Aurélie Cobat ^{1, 2} Luigi D. Notarangelo ³ Laurent Abel ¹ Jean-Christophe Richard ^{62, 63} Helen Su ³ Jean-Laurent Casanova ^{1, 2, 38, 64, *} Christelle Tual ⁶⁵ yazdan yazdanpanah ⁵⁸

* Corresponding author

1 Equipe Inserm U1163 - Human genetics of infectious diseases : Mendelian predisposition

Imagine - U1163 - Imagine - Institut des maladies génétiques (IHU)

2 Rockefeller University [New York]

3 NIAID-NIH - National Institute of Allergy and Infectious Diseases [Bethesda]

4 CIMI - Centre d'Immunologie et des Maladies Infectieuses

5 University of Tartu

6 HCL - Hospices Civils de Lyon

7 CIRI - Centre International de Recherche en Infectiologie - UMR

8 RAISE - Centre de référence des rhumatismes inflammatoires et maladies auto-immunes systémiques rares de l’enfant / National Referee Centre for Rheumatic and AutoImmune and Systemic Diseases in Children [Lyon]

9 LIFe - Lyon Immunopathology Federation

10 Tartu University Hospital [Tartu, Estonia]

11 Hôpital Foch [Suresnes]

12 Hôpital Avicenne [AP-HP]

13 H&P - Hypoxie et Poumon : pneumopathologies fibrosantes, modulations ventilatoires et circulatoires

14 Helix [San Mateo, CA]

15 University Medical Center [Utrecht]

16 IRCCS Ospedale San Raffaele [Milan, Italy]

17 UniSR - Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie]

18 YSM - Yale School of Medicine [New Haven, Connecticut]

19 IThEM - U1140 - Innovations thérapeutiques en hémostase

20 Equipe Inserm U1163 - Immunogenetics of pediatric autoimmune diseases

Imagine - U1163 - Imagine - Institut des maladies génétiques (IHU)

21 Centre National de Référence Maladies auto-immunes Systémiques Rares [CHU Pitié-Salpêtrière]

DMIIC - Service de Département de médecine interne et immunologie clinique [CHU Pitié-Salpêtrière]

22 UPCité - Université Paris Cité

23 Immunologie Translationnelle - Translational Immunology lab

24 Génétique Evolutive Humaine - Human Evolutionary Genetics

25 Chaire Génomique humaine et évolution

26 Amsterdam Neuroscience [Pays-Bas]

27 MUHC - McGill University Health Center [Montreal]

28 Garvan Institute of Medical Research [Darlinghurst, Australia]

29 UNSW - University of New South Wales [Sydney]

30 Ghent University Hospital

31 Hospital Universitario Mutua de Terrassa

32 UB - Universitat de Barcelona

33 IGTP - Institut d’Investigació Germans Trias i Pujol = Germans Trias i Pujol Research Institute

34 Universitat de Vic-Universitat Central de Catalunya, España

35 ICREA - Institució Catalana de Recerca i Estudis Avançats

36 Karolinska Institutet [Stockholm]

37 Karolinska University Hospital [Stockholm]

38 HHMI - Howard Hughes Medical Institute [New York]

39 Hospital Universitario de Gran Canaria Dr Negrin

40 University Fernando Pessoa - UFP

41 CNRGH - Centre National de Recherche en Génomique Humaine

42 Aarhus University Hospital

43 Aarhus University [Aarhus]

44 NIH - National Institutes of Health [Bethesda]

45 UNIMIB - Università degli Studi di Milano-Bicocca [Milano]

46 Fondazione MBBM-Ospedale [Monza, Italie]

47 San Gerardo Hospital of Monza

48 CIC-P - Centre d'investigation clinique plurithématique Pierre Drouin [Nancy]

49 Service d'Anesthésie réanimation [CHU Pitié-Salpêtrière]

50 UiB - University of Bergen

51 Haukeland University Hospital

52 CNR - Consiglio Nazionale delle Ricerche [Napoli]

53 Azienda Socio Sanitaria Territoriale Spedali Civili di Brescia [Brescia]

54 Università degli Studi di Brescia [Brescia]

55 Università degli Studi di Pavia

56 Fondazione IRCCS Policlinico San Matteo

57 CIC - CHU Bichat

58 AP-HP - Hôpital Bichat - Claude Bernard [Paris]

59 IAME (UMR_S_1137 / U1137) - Infection, Anti-microbiens, Modélisation, Evolution

60 UPC Médecine Paris Nord - Université Paris Cité - UFR Médecine Paris Nord [Santé]

61 Service d'Immunologie [CHU Pitié-Salpétrière]

62 CREATIS - Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé

63 MYRIAD - Modeling & analysis for medical imaging and Diagnosis

CREATIS - Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé

64 Service d'immuno-hématologie pédiatrique [CHU Necker]

65 CIC - Centre d'Investigation Clinique [Rennes]

Abstract : Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-ω (IFN-ω) (13 patients), against the 13 types of IFN-α (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Immunology

Life Sciences [q-bio] / Genetics

Complete list of metadata

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https://hal-pasteur.archives-ouvertes.fr/pasteur-02958871
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Submitted on : Tuesday, October 6, 2020 - 12:12:33 PM
Last modification on : Thursday, June 30, 2022 - 3:40:14 AM
Long-term archiving on: : Thursday, January 7, 2021 - 6:23:57 PM