Autoantibodies against type I IFNs in patients with life-threatening COVID-19
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Paul Bastard
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- Function : Correspondent author
- PersonId : 1079712
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Qian Zhang
- Function : Author
- PersonId : 768070
- ORCID : 0000-0002-9040-3289
Eleftherios Michailidis
- Function : Author
- PersonId : 798302
- ORCID : 0000-0002-9907-4346
Hans-Heinrich Hoffmann
- Function : Author
- PersonId : 775835
- ORCID : 0000-0003-0554-0244
Karim Dorgham
- Function : Author
- PersonId : 759824
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- IdRef : 123968445
Jérémie Rosain
- Function : Author
- PersonId : 802711
- ORCID : 0000-0002-2822-161X
Vivien Béziat
- Function : Author
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- ORCID : 0000-0002-4020-824X
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Jérémy Manry
- Function : Author
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Elana Shaw
- Function : Author
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Lazaro Lorenzo
- Function : Author
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Lucy Bizien
- Function : Author
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Sophie Trouillet-Assant
- Function : Author
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Kerry Dobbs
- Function : Author
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Alexandre Belot
- Function : Author
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Yacine Tandjaoui-Lambiotte
- Function : Author
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Gaspard Kerner
- Function : Author
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Benedetta Bigio
- Function : Author
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Yoann Seeleuthner
- Function : Author
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Rui Yang
- Function : Author
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Alexandre Bolze
- Function : Author
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Alessandro Aiuti
- Function : Author
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Giorgio Casari
- Function : Author
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Vito Lampasona
- Function : Author
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Lorenzo Piemonti
- Function : Author
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Fabio Ciceri
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Kaya Bilguvar
- Function : Author
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David Smadja
- Function : Author
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Mélanie Migaud
- Function : Author
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Benjamin Terrier
- Function : Author
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Darragh Duffy
- Function : Author
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- IdHAL : darragh-duffy
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Lluis Quintana-Murci
- Function : Author
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- IdHAL : lluis-quintana-murci
Diederik van de Beek
- Function : Author
- PersonId : 763698
- ORCID : 0000-0002-4571-044X
Lucie Roussel
- Function : Author
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Filomeen Haerynck
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David Dalmau
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Petter Brodin
- Function : Author
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Stéphanie Boisson-Dupuis
- Function : Author
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Carlos Rodríguez-Gallego
- Function : Author
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Paolo Bonfanti
- Function : Author
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Patrick Rossignol
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Luisa Imberti
- Function : Author
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Riccardo Castagnoli
- Function : Author
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Jade Ghosn
- Function : Author
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Anne Puel
- Function : Author
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Shen-Ying Zhang
- Function : Author
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Guy Gorochov
- Function : Author
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Emmanuelle Jouanguy
- Function : Author
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Aurélie Cobat
- Function : Author
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Laurent Abel
- Function : Author
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Jean-Christophe Richard
- Function : Author
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Helen Su
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- PersonId : 802727
- ORCID : 0000-0002-5582-9110
Jean-Laurent Casanova
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Abstract
Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-ω (IFN-ω) (13 patients), against the 13 types of IFN-α (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men.
Origin : Publication funded by an institution
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