Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity

Samuel Gonçalves (1) , Cláudio Duarte-Oliveira (1) , Cláudia Campos (1) , Vishukumar Aimanianda (2) , Rob Ter Horst (3) , Luis Leite , Toine Mercier , Paulo Pereira , Miguel Fernández-García , Daniela Antunes , Cláudia Rodrigues , Catarina Barbosa-Matos , Joana Gaifem , Inês Mesquita , António Marques , Nuno Osório , Egídio Torrado , Fernando Rodrigues , Sandra Costa , Leo Ab. Joosten , Katrien Lagrou , Johan Maertens , João Lacerda , António Campos , Gordon Brown (4) , Axel Brakhage , Coral Barbas , Ricardo Silvestre , Frank van de Veerdonk , Georgios Chamilos , Mihai Netea , Jean-Paul Latgé (2) , Cristina Cunha (1) , Agostinho Carvalho (1)

1 ICVS - Life and Health Sciences Research Institute [Braga]
2 Aspergillus
3 Radboud University Medical Center [Nijmegen]
4 University of Aberdeen

Domains: Life Sciences [q-bio]; Cellular Biology; Cell Behavior [q-bio.CB]

Samuel Gonçalves, Cláudio Duarte-Oliveira, Cláudia Campos, Vishukumar Aimanianda, Rob Ter Horst, et al.. Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity. Nature Communications, 2020, 11 (1), ⟨10.1038/s41467-020-16120-z⟩. ⟨pasteur-02942735⟩