A Unified Nomenclature and Amino Acid Numbering for Human PTEN

Rafael Pulido (1, 2) , Suzanne Baker (3) , João Barata (4) , Arkaitz Carracedo (2, 5, 6) , Victor Cid (7, 8) , Ian Chin-Sang (9) , Vrushank Davé (10, 11) , Jeroen den Hertog (12, 13) , Peter Devreotes (14) , Britta Eickholt (15) , Charis Eng (16, 17) , Frank Furnari (18) , Maria-Magdalena Georgescu (19) , Arne Gericke (20) , Benjamin Hopkins (21) , Xeujun Jiang (22) , Seung-Rock Lee (23) , Mathias Lösche (24, 25) , Prerna Malaney (11, 10) , Xavier Matias-Guiu (26, 27) , María Molina (7, 8) , Pier Paolo Pandolfi (28, 29) , Ramon Parsons (21) , Paolo Pinton (30) , Carmen Rivas (31, 32, 33) , Rafael Rocha (34) , Manuel Rodriguez (35) , Alonzo Ross (36) , Manuel Serrano (37) , Vuk Stambolic (38, 39, 40) , Bangyan Stiles (41) , Akira Suzuki (42) , Seong-Seng Tan (43) , Nicholas Tonks (44) , Lloyd Trotman (44) , Nicolas Wolff (45) , Rudiger Woscholski (46) , Hong Wu (47, 48) , Nicholas Leslie (49)

1 BioCruces Research Institute
2 Ikerbasque - Basque Foundation for Science
3 St Jude Children's Research Hospital
4 iMM - Instituto de Medicina Molecular
5 CIC bioGUNE - Center for Cooperative Research in Biosciences = Centro de Investigación cooperativa en biociencia (Derio, Biscay, Espagne)
6 UPV / EHU - University of the Basque Country = Euskal Herriko Unibertsitatea
7 IRYCIS - Instituto Ramon y Cajal de Investigacion Sanitaria [Madrid, Spain]
8 UCM - Universidad Complutense de Madrid = Complutense University of Madrid [Madrid]
9 Queen's University [Kingston, Canada]
10 H. Lee Moffitt Cancer Center and Research Institute
11 Morsani College of Medicine [Tampa, USA]
12 Hubrecht Institute [Utrecht, Netherlands]
13 IBL - Institute Biology Leiden
14 Johns Hopkins University School of Medicine [Baltimore]
15 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
16 Genomic Medicine Institute [Cleveland]
17 School of medicine [Cleveland, USA]
18 Ludwig Institute for Cancer Research
19 University of Texas Southwestern Medical Center [Dallas]
20 Worcester Polytechnic Institute
21 MSSM - Icahn School of Medicine at Mount Sinai [New York]
22 Memorial Sloane Kettering Cancer Center [New York]
23 Chonnam National University Medical School [Gwangju, South Korea]
24 CMU - Carnegie Mellon University [Pittsburgh]
25 NIST - National Institute of Standards and Technology [Gaithersburg]
26 Arnau de Vilanova University Hospital [Lleida, Spain]
27 IRBLleida - Biomedical Research Institute of Lleida [Spain]
28 BIDMC - Beth Israel Deaconess Medical Center [Boston]
29 HMS - Harvard Medical School [Boston]
30 UniFE - Università degli Studi di Ferrara = University of Ferrara
31 CNB-CSIC - Centro Nacional de Biotecnología [Madrid]
32 CiMUS-US - Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas [Barcelona, Spain]
33 Instituto de Investigaciones Sanitarias
34 A. C. Camargo Hospital [São Paulo]
35 Inbiomed [Spain]
36 UMASS - University of Massachusetts Medical School [Worcester]
37 CNIO - Spanish National Cancer Research Center
38 University of Toronto
39 Princess Margaret Hospital
40 University Health Network [Toronto, ON, Canada]
41 School of Pharmacy [USC, Los Angeles]
42 Graduate School of Medicine [Akita, Japan]
43 University of Melbourne
44 CSHL - Cold Spring Harbor Laboratory
45 Résonance Magnétique Nucléaire des Biomolécules
46 Department of Chemistry [Imperial College London]
47 UCLA - University of California [Los Angeles]
48 Peking University [Beijing]
49 HWU - Heriot-Watt University [Edinburgh]

The tumor suppressor PTEN is a major brake for cell transformation, mainly due to its phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3] phosphatase activity that directly counteracts the oncogenicity of phosphoinositide 3-kinase (PI3K). PTEN mutations are frequent in tumors and in the germ line of patients with tumor predisposition or with neurological or cognitive disorders, which makes the PTEN gene and protein a major focus of interest in current biomedical research. After almost two decades of intense investigation on the 403-residue-long PTEN protein, a previously uncharacterized form of PTEN has been discovered that contains 173 amino-terminal extra amino acids, as a result of an alternate translation initiation site. To facilitate research in the field and to avoid ambiguities in the naming and identification of PTEN amino acids from publications and databases, we propose here a unifying nomenclature and amino acid numbering for this longer form of PTEN.

Domaines: Sciences du Vivant [q-bio]; Biochimie, Biologie Moléculaire; Biologie moléculaire

Rafael Pulido, Suzanne Baker, João Barata, Arkaitz Carracedo, Victor Cid, et al.. A Unified Nomenclature and Amino Acid Numbering for Human PTEN. Science Signaling, 2014, 7 (332), pe15-pe15. ⟨10.1126/scisignal.2005560⟩. ⟨pasteur-02883975⟩