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A Unified Nomenclature and Amino Acid Numbering for Human PTEN

Rafael Pulido 1, 2, * Suzanne Baker 3 João Barata 4 Arkaitz Carracedo 2, 5, 6 Victor Cid 7, 8 Ian Chin-Sang 9 Vrushank Davé 10, 11 Jeroen den Hertog 12, 13 Peter Devreotes 14 Britta Eickholt 15 Charis Eng 16, 17 Frank Furnari 18 Maria-Magdalena Georgescu 19 Arne Gericke 20 Benjamin Hopkins 21 Xeujun Jiang 22 Seung-Rock Lee 23 Mathias Lösche 24, 25 Prerna Malaney 11, 10 Xavier Matias-Guiu 26, 27 María Molina 7, 8 Pier Paolo Pandolfi 28, 29 Ramon Parsons 21 Paolo Pinton 30 Carmen Rivas 31, 32, 33 Rafael Rocha 34 Manuel Rodriguez 35 Alonzo Ross 36 Manuel Serrano 37 Vuk Stambolic 38, 39, 40 Bangyan Stiles 41 Akira Suzuki 42 Seong-Seng Tan 43 Nicholas Tonks 44 Lloyd Trotman 44 Nicolas Wolff 45 Rudiger Woscholski 46 Hong Wu 47, 48 Nicholas Leslie 49
* Corresponding author
Abstract : The tumor suppressor PTEN is a major brake for cell transformation, mainly due to its phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3] phosphatase activity that directly counteracts the oncogenicity of phosphoinositide 3-kinase (PI3K). PTEN mutations are frequent in tumors and in the germ line of patients with tumor predisposition or with neurological or cognitive disorders, which makes the PTEN gene and protein a major focus of interest in current biomedical research. After almost two decades of intense investigation on the 403-residue-long PTEN protein, a previously uncharacterized form of PTEN has been discovered that contains 173 amino-terminal extra amino acids, as a result of an alternate translation initiation site. To facilitate research in the field and to avoid ambiguities in the naming and identification of PTEN amino acids from publications and databases, we propose here a unifying nomenclature and amino acid numbering for this longer form of PTEN.
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Submitted on : Monday, June 29, 2020 - 3:41:40 PM
Last modification on : Wednesday, October 14, 2020 - 4:09:53 AM

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Rafael Pulido, Suzanne Baker, João Barata, Arkaitz Carracedo, Victor Cid, et al.. A Unified Nomenclature and Amino Acid Numbering for Human PTEN. Science Signaling, American Association for the Advancement of Science, 2014, 7 (332), pe15-pe15. ⟨10.1126/scisignal.2005560⟩. ⟨pasteur-02883975⟩