Skip to Main content Skip to Navigation
Journal articles

Metabolic reprogramming: an innate cellular defence mechanism against intracellular bacteria?

Abstract : The limited metabolic resources of a cell represent an intriguing 'conflict of interest' during host-pathogen interactions, as the battle for nutrients might determine the outcome of an infection. To adapt their metabolic needs, innate immune cells such as monocytes, macrophages or dendritic cells reprogram their metabolism upon activation by microbial compounds. In turn, infection by intracellular bacteria provokes metabolic alterations of the host cell that benefit the pathogen. Here, we discuss the state-of-the-art knowledge on metabolic reprogramming of host cells upon activation or infection with intracellular bacteria. The study of the host-driven and pathogen-driven metabolic alterations that seem to co-exist during infection is an emerging field that will define the metabolic pathways that might be targeted to combat infection.
Document type :
Journal articles
Complete list of metadata

Cited literature [33 references]  Display  Hide  Download
Contributor : Isabelle HOFFMANN Connect in order to contact the contributor
Submitted on : Thursday, June 25, 2020 - 11:06:30 AM
Last modification on : Thursday, April 14, 2022 - 12:34:01 PM
Long-term archiving on: : Wednesday, September 23, 2020 - 4:01:04 PM


2019 Curr Opin Immunol_Escoll...
Files produced by the author(s)




Pedro Escoll, Carmen Buchrieser. Metabolic reprogramming: an innate cellular defence mechanism against intracellular bacteria?. Current Opinion in Immunology, Elsevier, 2019, Host pathogens, 60, pp.117-123. ⟨10.1016/j.coi.2019.05.009⟩. ⟨pasteur-02880718⟩



Record views


Files downloads