In-vitro and in-vivo models for hepatitis B cure research

Lena Allweiss (1) , Helene Strick-Marchand (2)

1 UKE - Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg]
2 Immunité Innée - Innate Immunity

Antiviral therapy for chronic hepatitis B infection is rarely curative, thus research in HBV cure strategies is a priority. Drug development and testing has been hampered by the lack of robust cell culture systems and small animal models. This review summarizes existing models for HBV cure research and focuses on recent developments since 2017 until today.

Domaines: Virologie

Lena Allweiss, Helene Strick-Marchand. In-vitro and in-vivo models for hepatitis B cure research. Current Opinion in HIV and AIDS, 2020, 15 (3), pp.173-179. ⟨10.1097/COH.0000000000000616⟩. ⟨pasteur-02875586⟩