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Prévention de la fibrose et du cancer du foie liés au virus de l’hépatite B en Afrique

Damien Cohen 1 Yusuke Shimakawa 2 Gibril Ndow 3 Amina Sow 3 Saydiba Tamba 3 Ramou Njie 4 Gora Lo 5 Sumantra Ghosh 1 Coumba Touré-Kane 3 Mourtalla Ka 5 Souleymane Mboup 5 Edith Okeke 6 Souleymane Toure 5 Madoky Diop 5 Umberto d'Alessandro 1 Simon Taylor-Robinson 3 Maimuna Mendy 7 Fabien Zoulim 1 Mark Thursz 3 Maud Lemoine 3 Isabelle Chemin 1, *
* Corresponding author
1 UNICANCER/CRCL - Centre de Recherche en Cancérologie de Lyon
2 Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology
3 Imperial College London
4 MRC - Medical Research Council Unit The Gambia
5 Hôpital Aristide-Le-Dantec
6 University of Jos [Nigeria]
7 CIRC - IARC - Centre International de Recherche contre le Cancer - International Agency for Research on Cancer
Abstract : Despite the existence of an effective vaccine, HBV infects 257 million people worldwide and is the cause of the majority of HCC. With an annual mortality rate of 887 000 patients in 2015, this cancer is the second deadliest. Low-income countries such as ones in sub-Saharan Africa are the most at risk due to the limited access to healthcare. To overcome this and born from an international research collaboration within an EU project, the Prolifica study aimed at evaluating a screen-and-treat program to prevent HBV complications, and more particularly HCC. Based on communities, facilities and hospitals HBsAg+ detection, the study lasted from 2011 to 2016. From the "cost effectiveness" feasibility of such a program to the development of simple scores for antiviral treatment, Prolifica uncovered data of crucial importance in a region with low HBV infection awareness, transmissions modes and prevention means which could have impacts on public health policies.
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PASTEUR | UNIV-LYON1 | CRCL | CNAM | CNRS | UDL | UNIV-HESAM | INSERM

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Damien Cohen, Yusuke Shimakawa, Gibril Ndow, Amina Sow, Saydiba Tamba, et al.. Prévention de la fibrose et du cancer du foie liés au virus de l’hépatite B en Afrique. médecine/sciences, EDP Sciences, 2019, 35 (5), pp.431-439. ⟨10.1051/medsci/2019076⟩. ⟨pasteur-02875225⟩

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