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Anti-Inflammatory Role for Intracellular Dimeric Immunoglobulin A by Neutralization of Lipopolysaccharide in Epithelial Cells

Abstract : Intestinal epithelial cells (IEC) play a central role in innate and acquired mucosal immunity. They ensure early signaling to trigger an inflammatory response against pathogens. Moreover, IEC mediate transcytosis of dimeric IgA (dIgA), through the polymeric-immunoglobulin receptor (pIgR), to provide secretory IgA, the major protective Ig in mucosal secretions. Using an in vitro model of polarized IEC, we describe an additional anti-inflammatory mechanism of dIgA-mediated protection against intracellular bacterial components involved in the proinflammatory activation of IEC. Specific dIgA colocalizes to lipopolysaccharide (LPS) in the apical recycling endosome compartment, preventing LPS-induced NF-kappaB translocation and subsequent proinflammatory response. Thus, intracellular neutralization by dIgA limits the acute local inflammation induced by proinflammatory pathogen-associated molecular patterns such as LPS.
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https://hal-pasteur.archives-ouvertes.fr/pasteur-02875032
Contributor : Armelle Phalipon <>
Submitted on : Friday, June 19, 2020 - 12:52:24 PM
Last modification on : Wednesday, July 29, 2020 - 11:10:48 AM

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M.Isabel Fernandez, Thierry Pedron, Régis Tournebize, Jean-Christophe Olivo-Marin, Philippe Sansonetti, et al.. Anti-Inflammatory Role for Intracellular Dimeric Immunoglobulin A by Neutralization of Lipopolysaccharide in Epithelial Cells. Immunity, Elsevier, 2003, 18 (6), pp.739-749. ⟨10.1016/S1074-7613(03)00122-5⟩. ⟨pasteur-02875032⟩

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