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La vaccination muqueuse cherche sa place parmi les nouvelles stratégies vaccinales.

Abstract : Among the many vaccine approaches developed in the recent past, mucosal vaccination has been a major focus. Oral vaccination has been particularly studied for the development of vaccines against enteric pathogens. To induce a local immune response, protective antigens have to be targeted to the intestinal mucosa-associated lymphoid follicles. Two types of approaches are currently being developed: (1) live attenuated strains constructed by specific inactivation of virulence factors; (2) subunit vaccines using the purified protective antigens combined to a delivery system. Several vaccine candidates are promising (live attenuated strains for shigellosis; killed bacteria combined to the B subunit of cholera toxin, a potent mucosal adjuvant, for cholera). However, recent disappointing results (intussuception occuring following vaccination in children with a live rhesus-human reassortant rotavirus tetravalent vaccine; low immunogenicity of live bacterial attenuated strains tested in endemic areas...) emphasize some limitations that remain to be solved. Innovative strategies are being investigated : intranasal vaccination inducing both systemic and local immune responses at different mucosal sites, edible plant vaccines... The future remains full of promise.
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Submitted on : Friday, June 19, 2020 - 12:19:29 PM
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Armelle Phalipon, Philippe Sansonetti. La vaccination muqueuse cherche sa place parmi les nouvelles stratégies vaccinales.. médecine/sciences, 2000, 16 (8-9), pp.905. ⟨10.4267/10608/1755⟩. ⟨pasteur-02874957⟩



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