Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors

Laurie Pinaud (1) , Philippe Sansonetti (1, 2) , Armelle Phalipon (1)

1 Pathogénie microbienne moléculaire
2 Collège de France - Chaire Microbiologie et Maladies infectieuses

Microbial pathogens possess a diversity of weapons that disrupt host homeostasis and immune defenses, thus resulting in the establishment of infection. The best-characterized system mediating bacterial protein delivery into target eukaryotic cells is the type III secretion system (T3SS) expressed by Gram-negative bacteria, including the human enteric pathogens Shigella, Salmonella, Yersinia, and enteropathogenic/enterohemorragic Escherichia coli (EPEC/EHEC). The emerging global view is that these T3SS-bearing pathogens share similarities in their ability to target key cellular pathways such as the cell cytoskeleton, trafficking, cell death/survival, and the NF-κB and MAPK signaling pathways. In particular, multiple host proteins are targeted in a given pathway, and different T3SS effectors from various pathogens share functional similarities.

Keywords: NF-κB and MAPK signaling pathways; cell cytoskeleton and trafficking; cell death and survival; host–pathogen cross-talk

Domains: Life Sciences [q-bio]; Microbiology and Parasitology; Bacteriology

Laurie Pinaud, Philippe Sansonetti, Armelle Phalipon. Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors. Trends in Microbiology, 2018, 26 (4), pp.266-283. ⟨10.1016/j.tim.2018.01.010⟩. ⟨pasteur-02874893⟩