Skip to Main content Skip to Navigation
Journal articles

Roles of Mitochondrial Respiratory Complexes during Infection

Abstract : Beyond oxidative phosphorylation (OXPHOS), mitochondria have also immune functions against infection, such as the regulation of cytokine production, the generation of metabolites with antimicrobial proprieties and the regulation of inflammasome-dependent cell death, which seem in turn to be regulated by the metabolic status of the organelle. Although OXPHOS is one of the main metabolic programs altered during infection, the mechanisms by which pathogens impact the mitochondrial electron transport chain (ETC) complexes to alter OXPHOS are not well understood. Similarly, how changes on ETC components affect infection is only starting to be characterized. Herein we summarize and discuss the existing data about the regulation of ETC complexes and super-complexes during infection, in order to shed some light on the mechanisms underlying the regulation of the mitochondrial OXPHOS machinery when intracellular pathogens infect eukaryotic host cells.
Document type :
Journal articles
Complete list of metadatas

Cited literature [61 references]  Display  Hide  Download

https://hal-pasteur.archives-ouvertes.fr/pasteur-02593579
Contributor : Isabelle Hoffmann <>
Submitted on : Friday, May 15, 2020 - 5:27:57 PM
Last modification on : Thursday, May 21, 2020 - 1:38:06 AM

File

2019 IJ Hapres_Escoll.pdf
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Collections

Citation

Pedro Escoll, Lucien Platon, Carmen Buchrieser. Roles of Mitochondrial Respiratory Complexes during Infection. Immunometabolism, Hapres, 2019, Immunometabolism and Inflammation, 1, pp.e190011. ⟨10.20900/immunometab20190011⟩. ⟨pasteur-02593579⟩

Share

Metrics

Record views

45

Files downloads

77