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Phages build anti-defence barriers

Abstract : Two recent studies reveal a virus anti-defence strategy whereby large, ‘jumbo’ phages protect themselves from both restriction endonucleases and DNA-targeting CRISPR–Cas systems, but not from RNA-targeting ones, by encapsulating the phage genome inside the cell in a ‘nucleus’-like shell that is impenetrable for CRISPR effectors.
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Submitted on : Thursday, June 11, 2020 - 12:35:33 PM
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Eugene V. Koonin, Mart Krupovic. Phages build anti-defence barriers. Nature Microbiology, Nature Publishing Group, 2020, 5 (1), pp.8-9. ⟨10.1038/s41564-019-0635-y⟩. ⟨pasteur-02559911⟩

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