Skip to Main content Skip to Navigation
Journal articles

Zebrafish Plzf transcription factors enhance early type I IFN response induced by two non-enveloped RNA viruses

Abstract : The BTB-POZ transcription factor Promyelocytic Leukemia Zinc Finger (PLZF, or ZBTB16) has been recently identified as a major factor regulating the induction of a subset of Interferon stimulated genes in human and mouse. We show that the two co-orthologues of PLZF found in zebrafish show distinct expression patterns, especially in larvae. Although zbtb16a/plzfa and zbtb16b/plzfb are not modulated by IFN produced during viral infection, their over-expression increases the level of the early type I IFN response, at a critical phase in the race between the virus and the host response. The effect of Plzfb on IFN induction was also detectable after cell infection by different non-enveloped RNA viruses, but not after infection by the rhabdovirus SVCV. Our findings indicate that plzf implication in the regulation of type I IFN responses is conserved across vertebrates, but at multiple levels of the pathway and through different mechanisms.
Complete list of metadatas

https://hal-pasteur.archives-ouvertes.fr/pasteur-02558296
Contributor : Valérie Briolat <>
Submitted on : Wednesday, April 29, 2020 - 2:41:06 PM
Last modification on : Thursday, June 18, 2020 - 1:20:03 PM

Identifiers

Collections

Citation

Elina Aleksejeva, Armel Houel, Valérie Briolat, Jean-Pierre Levraud, Christelle Langevin, et al.. Zebrafish Plzf transcription factors enhance early type I IFN response induced by two non-enveloped RNA viruses. Developmental and Comparative Immunology, Elsevier, 2016, 57, pp.48-56. ⟨10.1016/j.dci.2015.12.016⟩. ⟨pasteur-02558296⟩

Share

Metrics

Record views

33