Zebrafish Plzf transcription factors enhance early type I IFN response induced by two non-enveloped RNA viruses - Archive ouverte HAL Access content directly
Journal Articles Developmental and Comparative Immunology Year : 2016

Zebrafish Plzf transcription factors enhance early type I IFN response induced by two non-enveloped RNA viruses

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Abstract

The BTB-POZ transcription factor Promyelocytic Leukemia Zinc Finger (PLZF, or ZBTB16) has been recently identified as a major factor regulating the induction of a subset of Interferon stimulated genes in human and mouse. We show that the two co-orthologues of PLZF found in zebrafish show distinct expression patterns, especially in larvae. Although zbtb16a/plzfa and zbtb16b/plzfb are not modulated by IFN produced during viral infection, their over-expression increases the level of the early type I IFN response, at a critical phase in the race between the virus and the host response. The effect of Plzfb on IFN induction was also detectable after cell infection by different non-enveloped RNA viruses, but not after infection by the rhabdovirus SVCV. Our findings indicate that plzf implication in the regulation of type I IFN responses is conserved across vertebrates, but at multiple levels of the pathway and through different mechanisms.
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pasteur-02558296 , version 1 (29-04-2020)

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Elina Aleksejeva, Armel Houel, Valérie Briolat, Jean-Pierre Levraud, Christelle Langevin, et al.. Zebrafish Plzf transcription factors enhance early type I IFN response induced by two non-enveloped RNA viruses. Developmental and Comparative Immunology, 2016, 57, pp.48-56. ⟨10.1016/j.dci.2015.12.016⟩. ⟨pasteur-02558296⟩
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